1887

Abstract

SUMMARY: The production of a thermolabile, somatic antigenic modification by growth of in media containing serum has been demonstrated by agglutinin-absorption methods and by passive protection of mice against infection. Suspensions produced by growth in serum media have been termed OL-suspensions, to signify their possessing both the thermostable O-antigen, and a labile L-antigen.

OL-suspension stimulated the production of immune sera in rabbits which protected mice fully against infection with the homologous strain and partly against infection with the other strains tested. Such sera contained agglutinins against the thermostable O-antigens, agglutinins against the thermo-labile L-antigen and protective antibodies. The three types of antibodies apparently exist both as separate molecules and united in the same molecule, suggesting that the antigenic groups stimulating them exist united in the same antigenic molecules in the organism. The bearing of this suggested polyspecificity of the antigenic substance of upon previous work is discussed.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-1-2-211
1947-06-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/micro/1/2/mic-1-2-211.html?itemId=/content/journal/micro/10.1099/00221287-1-2-211&mimeType=html&fmt=ahah

References

  1. Burnet F. M. 1941 The Production of Antibodies p. 28 Melbourne: Macmillan and Co. Ltd;
    [Google Scholar]
  2. Dean H. R., Taylor G. L., Adair M. E. 1935; The precipitin reaction. Experiments with an antiserum containing two antibodies. J. Hyg., Camb 35:69
    [Google Scholar]
  3. Felix A., Bnatnagar S. S. 1935; Further observations on the properties of the Vi-antigen of B. typhosus and its corresponding antibody. Brit. J. exp. Path 16:422
    [Google Scholar]
  4. Felix A., Pitt R. M. 1984; Virulence of B. typhosus and resistance to O antibody. J. Path. Bact 38:409
    [Google Scholar]
  5. Gledhill A. W. 1945a; The antigenic structure of Erysipelothrix. J. Path. Bact 57:179
    [Google Scholar]
  6. Gledhill A. W. 1945b; The passive protection of mice against infection with E. rhusiopathiae. J. comp. Path 55:93
    [Google Scholar]
  7. Heidelberger M., Kendall F. E. 1934; Quantitative studies on the precipitin reaction. The role of multiple reactive groups in antigen-antibody union as illustrated by an instance of cross-precipitation. J. exp. Med 59:519
    [Google Scholar]
  8. Henderson D. W. 1937; A serological analysis of the protective substances in specific antibacterial sera which control experimental infection with Cl. oedematis maligni (Vibrion Septique). Brit. J. exp. Path 18:224
    [Google Scholar]
  9. Marrack J. R. 1938; The chemistry of antigens and antibodies. Spec. Rep. Ser. med. res. Coun., Lond230
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-1-2-211
Loading
/content/journal/micro/10.1099/00221287-1-2-211
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error