Microbiological Aspects of the Submerged-Culture Production of Penicillin on a Pilot-Plant Scale

References

1. Abraham E. P., Chain E., Fletcher C. M., Gardner D. A., Heatley N. G., Jennings M. A., Florey H. W. 1941; Further observations on penicillin. Lancet ii:177
   [Google Scholar]
2. Appleby J. C., Knowles E., Mcallister R. C. A., Pearson J., White T. 1947; The production of tyrothricin by submerged culture of Bacillus brevis in synthetic media. J. gen. Microbiol 1:145
   [Google Scholar]
3. Appleby J. C., Knowles E., Pearson J., White T. 1947; A preliminary study of the formation, assay and stability of tyrothricin. J. gen. Microbiol 1:137
   [Google Scholar]
4. Beadle G. W., Mitchell H. K., Bonner D. 1945; Improvements in the cylinder-plate method for penicillin assay. J. Bact 49:101
   [Google Scholar]
5. Clutterbuck P. W., Lovell R., Raistrick H. 1932; Studies in the biochemistry of micro-organisms. XXVI. The formation from glucose by members of the Penicillium chrysogenum series of a pigment, an alkali-soluble protein and penicillin-the antibacterial substance of Fleming. Biochem. J 26:1907
   [Google Scholar]
6. Fleming A. 1929; On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenzae. Brit. J. exp. Path 10:226
   [Google Scholar]
7. Foster J. W., Woodruff H. B. 1943; Microbiological aspects of penicillin. I. Methods of assay. J. Bact 46:187
   [Google Scholar]
8. Foster J. W., Woodruff H. B. 1944; Microbiological aspects of penicillin. VI. Procedure for the cup assay for penicillin. J. Bact 47:43
   [Google Scholar]
9. Foster J. W., Woodruff H. B., Mcdaniel L. E. 1943; Microbiological aspects of penicillin. III. Production of penicillin in surface cultures of Penicillium notatum. J. Bact 46:421
   [Google Scholar]
10. Gordon J. J., Grenfell E., Knowles E., Legge B. J., Mcallister R. C. A., White T. 1947; Methods of penicillin production in submerged culture on a pilot-plant scale. J. gen. Microbiol 1:187
    [Google Scholar]
11. Hanson H. J., Myers W. G., Stahly G. L., Birkeland J. M. 1946; Variation in Penicillium notatum induced by the bombardment of spores with neutrons. J. Bact 51:9
    [Google Scholar]
12. Knudsen L. F., Randall W. A. 1945; Penicillin assay and its control chart analysis. J. Bact 50:187
    [Google Scholar]
13. Koffler H., Emerson A. L., Perlman D., Burris R. M. 1945; Chemical changes in submerged penicillin fermentations. J. Bact 50:517
    [Google Scholar]
14. Moyer A. J., Coghill R. D. 1946a; Penicillin. VIII. Production of penicillin in surface cultures. J. Bact 51:57
    [Google Scholar]
15. Moyer A. J., Coghill R. D. 1946b; Penicillin. IX. The laboratory scale production of penicillin in submerged cultures by Penicillium notatum Westling (NRRL 832). J. Bact 51:79
    [Google Scholar]
16. Rahn O. 1945; Physical methods of sterilization of micro-organisms. Bact. Rev 9:1
    [Google Scholar]
17. Raper K. B., Alexander D. F., Coghill R. D. 1944; Penicillin. II. Natural variation and penicillin production in Penicillium notatum and allied species. J. Bact 48:639
    [Google Scholar]
18. Raper K. B., Fennel D. I. 1946; The production of penicillin X in submerged culture. J. Bact 51:761
    [Google Scholar]
19. Reyniers J. A. 1943 Micrurgical and Germ-free Methods Baltimore: Thomas;
    [Google Scholar]
20. Schmidt W. M., Moyer A. J. 1944; Penicillin. I. Methods of assay. J. Bact 47:199
    [Google Scholar]
21. Thom C., Raper K. B. 1945 A Manual of the Aspergilli Baltimore: Williams and Wilkins;
    [Google Scholar]