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Microbial Genomics logo Microbial Genomics

Volume 11, Issue 11

Identification and response to a putatively hypervirulent, carbapenem-resistant ST395 hospital outbreak in the UK Open Access

Abstract

Here, we describe a putatively hypervirulent, carbapenem-resistant (hv-CRKP) outbreak. Nanopore sequencing guided the infection prevention and control (IPC) responses during the outbreak. Twelve patients were identified as either being colonized and/or having clinical infections with the putative hv-CRKP, with an all-cause mortality within 6 months of 36%. Multiple IPC responses were put in place, with enhanced cleaning of the environment being the key intervention to halt the outbreak. All isolates were ST395 and contained at least one carbapenemase gene, along with a variable array of other antimicrobial resistance and virulence genes, due to a rapidly evolving set of plasmids.

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Keyword(s): hypervirulent, carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) , infection prevention and control (IPC) and nanopore sequencing
Funding
This study was supported by the:
  • Medical Research Council (Award MR/Y015037/1)
    • Principal Award Recipient: AlanMcNally
  • Birmingham Biomedical Research Centre (Award NIHR203326)
    • Principal Award Recipient: AlanMcNally
© 2025 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2025-11-20
2025-12-16

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Identification and response to a putatively hypervirulent, carbapenem-resistant Klebsiella pneumoniae ST395 hospital outbreak in the UK
M Gen 11, 001571 (2025); https://doi.org/10.1099/mgen.0.001571
/content/journal/mgen/10.1099/mgen.0.001571
/content/journal/mgen/10.1099/mgen.0.001571
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