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Microbial Genomics logo Microbial Genomics

Volume 11, Issue 4

Exploring the microbial communities in coastal cenote and their hidden biotechnological potential Open Access

Abstract

Bacterial secondary metabolites are crucial bioactive compounds with significant therapeutic potential, playing key roles in ecological processes and the discovery of novel antimicrobial agents and natural products. Cenotes, as extreme environments, harbour untapped microbial diversity and hold an interesting potential as sources of novel secondary metabolites. While research has focused on the fauna and flora of cenotes, the study of their microbial communities and their biosynthetic capabilities remains limited. Advances in metagenomics and genome sequencing have greatly improved the capacity to explore these communities and their metabolites. In this study, we analysed the microbial diversity and biotechnological potential of micro-organisms inhabiting sediments from a coastal cenote. Metagenomic analyses revealed a rich diversity of bacterial and archaeal communities, containing several novel biosynthetic gene clusters (BGCs) linked to secondary metabolite production. Notably, polyketide synthase BGCs, including those encoding ladderanes and aryl-polyenes, were identified. Bioinformatics analyses of these pathways suggest the presence of compounds with potential industrial and pharmaceutical applications. These findings highlight the biotechnological value of cenotes as reservoirs of secondary metabolites. The study and conservation of these ecosystems are essential to facilitate the discovery of new bioactive compounds that could benefit various industries.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): biosynthetic gene clusters , coastal cenotes , metagenomics and secondary metabolites
Funding
This study was supported by the:
  • Consejo Nacional de Ciencia y Tecnología (Award 788622)
    • Principle Award Recipient: PerlaContreras-de la Rosa
  • Consejo Nacional de Ciencia y Tecnología (Award INFR-2016-01-269833)
    • Principle Award Recipient: AileenO´Connor-Sánchez
  • Consejo Nacional de Ciencia y Tecnología (Award A1-S-10785)
    • Principle Award Recipient: AlejandraPrieto-Davó
© 2025 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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Exploring the microbial communities in coastal cenote and their hidden biotechnological potential
M Gen 11, 001382 (2025); https://doi.org/10.1099/mgen.0.001382
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