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Volume 10, Issue 11

Pan-genomic characterization and structural variant analysis reveal insights into spore development and species diversity in Open Access

Abstract

Understanding the genomic diversity and functional implications of species is crucial for elucidating their evolutionary history and biotechnological potential. Here, we present the first pan-genomic analysis of spp., combining five newly sequenced genomes with ten publicly available genomes. Our comprehensive comparative study unveiled a rich genomic landscape, identifying core genes shared among all strains and species-specific gene sets. Additionally, we identified structural variants impacting the expression of key genes, including insights into the gene involved in DNA repair and recombination processes, which exhibits a 440 bp insertion in the promoter region and a leucine-to-serine mutation in the gene body, potentially increasing spore production in the S3 strain. Overall, our study provides valuable insights into the genomic architecture and functional diversity of , paving the way for further research on its evolutionary dynamics, biotechnological applications and pharmaceutical potential.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Ganoderma , MSH4 , pan-genome , spore development and structural variation
Funding
This study was supported by the:
  • School management project of Fujian University of Traditional Chinese Medicine (Award X2021001)
    • Principal Award Recipient: XiaoyanLi
  • School management project of Fujian University of Traditional Chinese Medicine (Award XJC2023011)
    • Principal Award Recipient: WenXu
  • Science and Technology Planning Project of Fuzhou (Award 2023-P-005)
    • Principal Award Recipient: ZehaoHuang
  • Fujian Provincial Department of Science and Technology (Award 2022Y4017)
    • Principal Award Recipient: YuLin
  • National Key R&D Program of China (Award 2019YFC1710505)
    • Principal Award Recipient: YuLin
  • State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources (Award SKLCUSA-b202302)
    • Principal Award Recipient: HaifengWang
  • Sugarcane Research Foundation of Guangxi University (Award 2022GZA002)
    • Principal Award Recipient: HaifengWang
  • Natural Science Foundation of Guangxi Zhuang Autonomous Region (Award 2023GXNSFDA026034)
    • Principal Award Recipient: HaifengWang
  • National Natural Science Foundation of China (Award 32160142)
    • Principal Award Recipient: HaifengWang
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2025-11-12

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Pan-genomic characterization and structural variant analysis reveal insights into spore development and species diversity in Ganoderma
M Gen 10, 001328 (2024); https://doi.org/10.1099/mgen.0.001328
/content/journal/mgen/10.1099/mgen.0.001328
/content/journal/mgen/10.1099/mgen.0.001328
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