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Microbial Genomics logo Microbial Genomics

Volume 10, Issue 10

Genomics unveils country-to-country transmission between animal hospitals of a multidrug-resistant and sequence type 2 clone Open Access

Abstract

is a globally distributed opportunistic pathogen in human health settings, including in intensive care units (ICUs). We investigated the contamination of a French small animal ICU with . We discovered repeated animal contamination by , and phylogenetic analysis traced contamination back to a potential foreign animal origin. Genomic analysis combined with antibiotic susceptibility testing revealed heteroresistance to penicillin and aminoglycoside mediated by insertion sequence dynamics and also suggest a potential cross-resistance to human-restricted piperacillin–tazobactam combination. The isolates of the animal ICU belong to the International Clone 2 commonly found in human health settings. Our results suggest a high adaptation of this lineage to healthcare settings and provide questions on the requirements for genetic determinants enabling adaptation to host and abiotic conditions.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Acinetobacter baumannii , antibiotic resistance , resistance island and zoonosis
Funding
This study was supported by the:
  • Fondation pour la Recherche Médicale (FR) (Award EQU202303016268)
    • Principle Award Recipient: XavierCharpentier
  • Agence Nationale de la Recherche (FR) (Award ANR-11-IDEX-0007)
    • Principle Award Recipient: XavierCharpentier
  • Agence Nationale de la Recherche (FR) (Award ANR-11-LABX-0048)
    • Principle Award Recipient: XavierCharpentier
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2024-10-14
2025-07-16
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Genomics unveils country-to-country transmission between animal hospitals of a multidrug-resistant and sequence type 2 Acinetobacter baumannii clone
M Gen 10, 001292 (2024); https://doi.org/10.1099/mgen.0.001292
/content/journal/mgen/10.1099/mgen.0.001292
/content/journal/mgen/10.1099/mgen.0.001292
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