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Microbial Genomics logo Microbial Genomics

Volume 10, Issue 5

Inferring diet, disease and antibiotic resistance from ancient human oral microbiomes Open Access

Abstract

The interaction between a host and its microbiome is an area of intense study. For the human host, it is known that the various body-site-associated microbiomes impact heavily on health and disease states. For instance, the oral microbiome is a source of various pathogens and potential antibiotic resistance gene pools. The effect of historical changes to the human host and environment to the associated microbiome, however, has been less well explored. In this review, we characterize several historical and prehistoric events which are considered to have impacted the oral environment and therefore the bacterial communities residing within it. The link between evolutionary changes to the oral microbiota and the significant societal and behavioural changes occurring during the pre-Neolithic, Agricultural Revolution, Industrial Revolution and Antibiotic Era is outlined. While previous studies suggest the functional profile of these communities may have shifted over the centuries, there is currently a gap in knowledge that needs to be filled. Biomolecular archaeological evidence of innate antimicrobial resistance within the oral microbiome shows an increase in the abundance of antimicrobial resistance genes since the advent and widespread use of antibiotics in the modern era. Nevertheless, a lack of research into the prevalence and evolution of antimicrobial resistance within the oral microbiome throughout history hinders our ability to combat antimicrobial resistance in the modern era.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): ancient DNA , antibiotic resistance and evolution
Funding
This study was supported by the:
  • University of Bradford
    • Principle Award Recipient: FrancescaStandeven
  • University of Bradford
    • Principle Award Recipient: GwynDahlquist-Axe
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-05-13
2025-04-30
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Inferring diet, disease and antibiotic resistance from ancient human oral microbiomes
M Gen 10, 001251 (2024); https://doi.org/10.1099/mgen.0.001251
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