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Abstract

Existing tools for phylogeographic and epidemiological visualisation primarily provide a macro-geographic view of epidemic and pandemic transmission events but offer little support for detailed investigation of outbreaks in healthcare settings. Here, we present HAIviz, an interactive web-based application designed for integrating and visualising genomic epidemiological information to improve the tracking of healthcare-associated infections (HAIs). HAIviz displays and links the outbreak timeline, building map, phylogenetic tree, patient bed movements, and transmission network on a single interactive dashboard. HAIviz has been developed for bacterial outbreak investigations but can be utilised for general epidemiological investigations focused on built environments for which visualisation to customised maps is required. This paper describes and demonstrates the application of HAIviz for HAI outbreak investigations.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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/content/journal/mgen/10.1099/mgen.0.001200
2024-02-15
2025-04-29
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References

  1. Snitkin ES, Zelazny AM, Thomas PJ, Stock F, Henderson DK et al. Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing. Sci Transl Med 2012; 4:148ra116 [View Article] [PubMed]
    [Google Scholar]
  2. Zhou K, Lokate M, Deurenberg RH, Tepper M, Arends JP et al. Use of whole-genome sequencing to trace, control and characterize the regional expansion of extended-spectrum β-lactamase producing ST15 Klebsiella pneumoniae. Sci Rep 2016; 6:20840 [View Article] [PubMed]
    [Google Scholar]
  3. Rosendahl Madsen AM, Holm A, Jensen TG, Knudsen E, Lundgaard H et al. Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires’ disease. J Hosp Infect 2017; 96:392–395 [View Article] [PubMed]
    [Google Scholar]
  4. Forde BM, Bergh H, Cuddihy T, Hajkowicz K, Hurst T et al. Clinical implementation of routine whole-genome sequencing for hospital infection control of multi-drug resistant pathogens. Clin Infect Dis 2022 [View Article]
    [Google Scholar]
  5. Higgs C, Sherry NL, Seemann T, Horan K, Walpola H et al. Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings. Nat Commun 2022; 13:509 [View Article] [PubMed]
    [Google Scholar]
  6. Permana B, Harris PNA, Runnegar N, Lindsay M, Henderson BC et al. Using genomics to investigate an outbreak of vancomycin-resistant Enterococcus faecium ST78 at a large tertiary hospital in Queensland. Microbiol Spectr 2023; 11:e0420422 [View Article] [PubMed]
    [Google Scholar]
  7. Cuddihy T, Harris PNA, Permana B, Beatson SA, Forde BM. CATHAI: cluster analysis tool for healthcare-associated infections. Bioinform Adv 2022; 2:vbac040 [View Article] [PubMed]
    [Google Scholar]
  8. Jombart T, Eggo RM, Dodd PJ, Balloux F. Reconstructing disease outbreaks from genetic data: a graph approach. Heredity 2011; 106:383–390 [View Article] [PubMed]
    [Google Scholar]
  9. Jombart T, Cori A, Didelot X, Cauchemez S, Fraser C et al. Bayesian reconstruction of disease outbreaks by combining epidemiologic and genomic data. PLoS Comput Biol 2014; 10:e1003457 [View Article] [PubMed]
    [Google Scholar]
  10. De Maio N, Wu C-H, Wilson DJ, Koelle K. SCOTTI: efficient reconstruction of transmission within outbreaks with the structured coalescent. PLoS Comput Biol 2016; 12:e1005130 [View Article]
    [Google Scholar]
  11. Argimón S, Abudahab K, Goater RJE, Fedosejev A, Bhai J et al. Microreact: visualizing and sharing data for genomic epidemiology and phylogeography. Microb Genom 2016; 2:e000093 [View Article] [PubMed]
    [Google Scholar]
  12. Argimón S, Yeats CA, Goater RJ, Abudahab K, Taylor B et al. A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch. Nat Commun 2021; 12:2879 [View Article] [PubMed]
    [Google Scholar]
  13. Hadfield J, Megill C, Bell SM, Huddleston J, Potter B et al. Nextstrain: real-time tracking of pathogen evolution. Bioinformatics 2018; 34:4121–4123 [View Article] [PubMed]
    [Google Scholar]
  14. Bartley PB, Ben Zakour NL, Stanton-Cook M, Muguli R, Prado L et al. Hospital-wide eradication of a nosocomial Legionella pneumophila serogroup 1 outbreak. Clin Infect Dis 2016; 62:273–279 [View Article] [PubMed]
    [Google Scholar]
  15. Palmore TN, Stock F, White M, Bordner M, Michelin A et al. A cluster of cases of nosocomial legionnaires disease linked to a contaminated hospital decorative water fountain. Infect Control Hosp Epidemiol 2009; 30:764–768 [View Article] [PubMed]
    [Google Scholar]
  16. Osawa K, Shigemura K, Abe Y, Jikimoto T, Yoshida H et al. A case of nosocomial Legionella pneumonia associated with a contaminated hospital cooling tower. J Infect Chemother 2014; 20:68–70 [View Article] [PubMed]
    [Google Scholar]
  17. Beatson SA, Bartley PB. Diving deep into hospital-acquired Legionella pneumophila with whole-genome sequencing. Clin Infect Dis 2017; 64:1260–1262 [View Article] [PubMed]
    [Google Scholar]
  18. Jarvis WR, Munn VP, Highsmith AK, Culver DH, Hughes JM. The epidemiology of nosocomial infections caused by Klebsiella pneumoniae. Infect Control 1985; 6:68–74 [View Article] [PubMed]
    [Google Scholar]
  19. Ulrich N, Vonberg RP, Gastmeier P. Outbreaks caused by vancomycin-resistant Enterococcus faecium in hematology and oncology departments: a systematic review. Heliyon 2017; 3:e00473 [View Article] [PubMed]
    [Google Scholar]
  20. Franz M, Lopes CT, Huck G, Dong Y, Sumer O et al. Cytoscape.js: a graph theory library for visualisation and analysis. Bioinformatics 2016; 32:309–311 [View Article] [PubMed]
    [Google Scholar]
  21. Gansner ER, North SC. An open graph visualization system and its applications to software engineering. Softw: Pract Exper 2000; 30:1203–1233 [View Article]
    [Google Scholar]
  22. Campbell F, Didelot X, Fitzjohn R, Ferguson N, Cori A et al. outbreaker2: a modular platform for outbreak reconstruction. BMC Bioinformatics 2018; 19:363 [View Article] [PubMed]
    [Google Scholar]
  23. Csardi G, Nepusz T. The Igraph software package for complex network research. InterJournal 2006; Complex Systems: p:1695
    [Google Scholar]
  24. Permana B, Beatson SA, Forde BM. GraphSNP: an interactive distance viewer for investigating outbreaks and transmission networks using a graph approach. BMC Bioinformatics 2023; 24:209 [View Article] [PubMed]
    [Google Scholar]
  25. Roberts LW, Forde BM, Hurst T, Ling W, Nimmo GR et al. Genomic surveillance, characterization and intervention of a polymicrobial multidrug-resistant outbreak in critical care. Microb Genom 2021; 7:mgen000530 [View Article] [PubMed]
    [Google Scholar]
  26. Chung The H, Karkey A, Pham Thanh D, Boinett CJ, Cain AK et al. A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae. EMBO Mol Med 2015; 7:227–239 [View Article] [PubMed]
    [Google Scholar]
  27. Hackeloeer A, Klasing K, Krisp JM, Meng L. Georeferencing: a review of methods and applications. Annals of GIS 2014; 20:61–69 [View Article]
    [Google Scholar]
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