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Volume 10, Issue 1

biosynthetic gene cluster diversity highlights the need for broad-spectrum investigations Open Access

Abstract

Investigations of the bacterial family have enabled the development of secondary metabolites critical to human health. Historical investigation of bacterial families for natural product discovery has focused on terrestrial strains, where time-consuming isolation processes often lead to the rediscovery of known compounds. To investigate the secondary metabolite potential of marine-derived , 38 strains were sequenced, assembled and analysed using antiSMASH and BiG-SLiCE. BiG-SLiCE contains a near-comprehensive dataset of approximately 1.2 million publicly available biosynthetic gene clusters from primarily terrestrial strains. Our marine-derived were directly compared to BiG-SLiCE’s preprocessed database using BiG-SLiCE’s query mode; genetic diversity within our strains was uncovered using BiG-SCAPE and metric multidimensional scaling analysis. Our analysis of marine-derived emphasizes the clear need for broader genomic investigations of marine strains to fully realize their potential as sources of new natural products.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): biosynthetic gene cluster , drug discovery , genomics , marine-derived and natural products
Funding
This study was supported by the:
  • National Institutes of Health (US) (Award T32GM008349)
    • Principle Award Recipient: ImraanAlas
  • National Institutes of Health (US) (Award R01AT009874)
    • Principle Award Recipient: TimS. Bugni
  • National Institutes of Health (US) (Award U19AI142720)
    • Principle Award Recipient: TimS. Bugni
  • National Institutes of Health (US) (Award U19AI109673)
    • Principle Award Recipient: TimS. Bugni
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-12-03
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Micromonosporaceae biosynthetic gene cluster diversity highlights the need for broad-spectrum investigations
M Gen 10, 001167 (2024); https://doi.org/10.1099/mgen.0.001167
/content/journal/mgen/10.1099/mgen.0.001167
/content/journal/mgen/10.1099/mgen.0.001167
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