1887

Microbial Genomics logo

Volume 8, Issue 11

Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 isolates from healthy pigs Open Access

Abstract

is a leading cause of bacterial meningitis in South-East Asia, with frequent zoonotic transfer to humans associated with close contact with pigs. A small number of invasive lineages are responsible for endemic infection in the swine industry, causing considerable global economic losses. A lack of surveillance and a rising trend in clinical treatment failure has raised concerns of growing antimicrobial resistance (AMR) among invasive . Gene flow between healthy and disease isolates is poorly understood and, in this study, we sample and sequence a collection of isolates predominantly from healthy pigs in Chiang Mai province, Northern Thailand. Pangenome characterization identified extensive genetic diversity and frequent AMR carriage in isolates from healthy pigs. Multiple AMR genes were identified, conferring resistance to aminoglycosides, lincosamides, tetracycline and macrolides. All isolates were non-susceptible to three or more different antimicrobial classes, and 75 % of non-serotype 2 isolates were non-susceptible to six or more classes (compared to 37.5 % of serotype 2 isolates). AMR genes were found on integrative and conjugative elements previously observed in other species, suggesting a mobile gene pool that can be accessed by invasive disease isolates. This article contains data hosted by Microreact.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antimicrobial resistance , gene pool transmission , meningitis , One Health and Streptococcus suis
Funding
This study was supported by the:
  • Medical Research Council (Award MR/V001213/1)
    • Principle Award Recipient: BenPascoe
  • Medical Research Council (Award MR/T030062/1)
    • Principle Award Recipient: K SheppardSamuel
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2022-11-03
2024-04-20
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http://instance.metastore.ingenta.com/content/journal/mgen/10.1099/mgen.0.000882
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Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs
M Gen 8, 000882 (2022); https://doi.org/10.1099/mgen.0.000882
/content/journal/mgen/10.1099/mgen.0.000882
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