1887

Abstract

Emerging evidence has identified viral circular RNAs (circRNAs) in human cells infected by viruses, interfering with the immune system and inducing diseases including human cancer. However, the biogenesis and regulatory mechanisms of virus-encoded circRNAs in host cells remain unknown. In this study, we used the circRNA detection tool CIRI2 to systematically determine the virus-encoded circRNAs in virus-infected cancer cell lines and cancer patients, by analysing RNA-Seq datasets derived from RNase R-treated samples. Based on the thousands of viral circRNAs we identified, the biological characteristics and potential roles of viral circRNAs in regulating host cell function were determined. In addition, we developed a Viral-circRNA Database (http://www.hywanglab.cn/vcRNAdb/), which is open to all users to search, browse and download information on circRNAs encoded by viruses upon infection.

Funding
This study was supported by the:
  • National Key Research and Development Program (Award 2017YFC0908500)
    • Principle Award Recipient: HaiyunWang
  • National Natural Science Foundation of China (Award 31771469)
    • Principle Award Recipient: HaiyunWang
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License.
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2022-06-22
2022-07-02
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