1887

Abstract

Increasing evidence of regional pathogen transmission networks highlights the importance of investigating the dissemination of multidrug-resistant organisms (MDROs) across a region to identify where transmission is occurring and how pathogens move across regions. We developed a framework for investigating MDRO regional transmission dynamics using whole-genome sequencing data and created , an easy-to-use, open source R package that implements these methods (https://github.com/Snitkin-Lab-Umich/regentrans). Using a dataset of over 400 carbapenem-resistant isolates of collected from patients in 21 long-term acute care hospitals over a one-year period, we demonstrate how to use our framework to gain insights into differences in inter- and intra-facility transmission across different facilities and over time. This framework and corresponding R package will allow investigators to better understand the origins and transmission patterns of MDROs, which is the first step in understanding how to stop transmission at the regional level.

Funding
This study was supported by the:
  • Michigan Institute for Clinical and Health Research Postdoctoral Translational Scholars Program
    • Principle Award Recipient: JoyceWang
  • Canadian Institutes of Health Research (Award 201711MFE-396343-165736)
    • Principle Award Recipient: JoyceWang
  • National Science Foundation (Award DGE 1256260)
    • Principle Award Recipient: ZenaLapp
  • National Institutes of Health (Award 1R01AI148259-01)
    • Principle Award Recipient: EvanS Snitkin
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2022-01-17
2024-07-19
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