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Volume 7, Issue 8

Genomics of (newly named ) reveals a new subgroup Open Access

Abstract

(newly named ) is an emerging pathogen in immunodeficient and immunocompetent patients. Most documented cases associated with are frequently catheter-related and exhibit wide-spectrum β-lactam resistance. Misidentification of this pathogen using commercial bacterial identification kits is common. We identified a case of infection associated with cholelithiasis. The genome was sequenced and reconstructed using a Nanopore and Illumina hybrid strategy. A novel divergent from existing OXA members was identified and subsequent analysis revealed its existence in all available genomes, which forms a new phylogenetic subgroup distinct from other OXA clusters. Further analysis demonstrated the presence of the novel in the chromosome of several other species. Our study indicated that chromosomes may be a reservoir of β-lactamases.

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  • Accepted:
  • Published Online:
Keyword(s): Brucella pseudogrignonensis , Ochrobactrum pseudogrignonense , OXA and β-lactamases
Funding
This study was supported by the:
  • Taichung Veteran General Hospital (Award TCVGH-NK1109004)
    • Principle Award Recipient: LiuPo-Yu
  • Taichung Veterans General Hospital (Award TCVGH-1103901C)
    • Principle Award Recipient: Po-YuLiu
  • Taichung Veterans General Hospital (Award TCVGH-1103901D)
    • Principle Award Recipient: Po-YuLiu
  • Ministry of Science and Technology, Taiwan (Award 109-2314-B-075A-009)
    • Principle Award Recipient: Po-YuLiu
  • Ministry of Science and Technology, Taiwan (Award 109-2221-E-194 -038 -MY3)
    • Principle Award Recipient: Yao-TingHuang
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2021-08-27
2024-04-24
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Genomics of Ochrobactrum pseudogrignonense (newly named Brucella pseudogrignonensis) reveals a new blaOXA subgroup
M Gen 7, 000626 (2021); https://doi.org/10.1099/mgen.0.000626
/content/journal/mgen/10.1099/mgen.0.000626
/content/journal/mgen/10.1099/mgen.0.000626
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