1887

Abstract

is a large and diverse phylum of bacteria that contains medically and ecologically relevant organisms. Many members are valuable sources of bioactive natural products and chemical precursors that are exploited in the clinic and made using the enzyme pathways encoded in their complex genomes. Whilst the number of sequenced genomes has increased rapidly in the last 20 years, the large size, complexity and high G+C content of many actinobacterial genomes means that the sequences remain incomplete and consist of large numbers of contigs with poor annotation, which hinders large-scale comparative genomic and evolutionary studies. To enable greater understanding and exploitation of actinobacterial genomes, specialized genomic databases must be linked to high-quality genome sequences. Here, we provide a curated database of 612 high-quality actinobacterial genomes from 80 genera, chosen to represent a broad phylogenetic group with equivalent genome re-annotation. Utilizing this database will provide researchers with a framework for evolutionary and metabolic studies, to enable a foundation for genome and metabolic engineering, to facilitate discovery of novel bioactive therapeutics and studies on gene family evolution. This article contains data hosted by Microreact.

Funding
This study was supported by the:
  • AnnaS Birke , GSK
  • AnnaS Birke , Industrial Biotechnology Innovation Centre (IBioIC) Studentship
  • JanaK Schniete , Mac Robertson Travelling Scholarship
  • PaulA Hoskisson , Scottish Universities Life Science Alliance (SULSA) , (Award BioSkape Studentship)
  • FranciscoBarona-Gomez , CONACyT , (Award Metabolic Robustness in Streptomyces)
  • FranciscoBarona-Gomez , Royal Society , (Award NAF\R2\18063)
  • PaulA Hoskisson , Royal Academy of Engineering , (Award Research Chair)
  • PaulA Hoskisson , Natural Environment Research Council , (Award NE/M001415/1)
  • PaulA Hoskisson , Biotechnology and Biological Sciences Research Council , (Award NPRONET POC045)
  • PaulA Hoskisson , Biotechnology and Biological Sciences Research Council , (Award BB/T001038/1)
  • PaulA Hoskisson , Biotechnology and Biological Sciences Research Council , (Award BB/N023544/1)
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2021-01-12
2021-01-21
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