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Volume 7, Issue 8

Phylum barrier and intra-species phylogeny drive the acquisition of antibiotic-resistance genes Open Access

Abstract

is a ubiquitous bacterium that has been widely exposed to antibiotics over the last 70 years. It has adapted by acquiring different antibiotic-resistance genes (ARGs), the census of which we aim to characterize here. To do so, we analysed 70 301 genomes obtained from the EnteroBase database and detected 1 027 651 ARGs using the AMRFinder, Mustard and ResfinderFG ARG databases. We observed a strong phylogroup and clonal lineage specific distribution of some ARGs, supporting the argument for epistasis between ARGs and the strain genetic background. However, each phylogroup had ARGs conferring a similar antibiotic class resistance pattern, indicating phenotypic adaptive convergence. The G+C content or the type of ARG was not associated with the frequency of the ARG in the database. In addition, we identified ARGs from anaerobic, non- bacteria in four genomes of , supporting the hypothesis that the transfer between anaerobic bacteria and can spontaneously occur but remains exceptional. In conclusion, we showed that phylum barrier and intra-species phylogenetic history are major drivers of the acquisition of a resistome in .

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antibiotic-resistance genes and Escherichia coli
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2021-08-26
2024-04-23
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Phylum barrier and Escherichia coli intra-species phylogeny drive the acquisition of antibiotic-resistance genes
M Gen 7, 000489 (2021); https://doi.org/10.1099/mgen.0.000489
/content/journal/mgen/10.1099/mgen.0.000489
/content/journal/mgen/10.1099/mgen.0.000489
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