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Volume 6, Issue 12

Genomic epidemiology of nontoxigenic from King County, Washington State, USA between July 2018 and May 2019 Open Access

Abstract

Between July 2018 and May 2019, was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Compared to publicly available genomic data, these WA isolates formed a discrete cluster with SNP variation consistent with previously reported outbreaks. Virulence-related gene content variation within the highly related WA cluster isolates was also observed. These results indicated that genome characterization can readily support epidemiology of nontoxigenic .

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): C. diphtheriae , genomics , nontoxigenic , SNP and virulence factor
Funding
This study was supported by the:
  • Centers for Disease Control and Prevention
    • Principle Award Recipient: NotApplicable
© Microbiology Society
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2020-12-04
2024-04-19
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Genomic epidemiology of nontoxigenic Corynebacterium diphtheriae from King County, Washington State, USA between July 2018 and May 2019
M Gen 6, e000467 (2020); https://doi.org/10.1099/mgen.0.000467
/content/journal/mgen/10.1099/mgen.0.000467
/content/journal/mgen/10.1099/mgen.0.000467
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