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Volume 5, Issue 10

Genomic epidemiology of penicillin-non-susceptible Open Access

Abstract

Penicillin-non-susceptible (PNSP) were first detected in the 1960s, and are now common worldwide, predominantly through the international spread of a limited number of strains. Extant PNSP are characterized by mosaic , and genes generated by interspecies recombinations, with the extent of these alterations determining the range and concentrations of β-lactams to which the genotype is non-susceptible. The complexity of the genetics underlying these phenotypes has been the subject of both molecular microbiology and genome-wide association and epistasis analyses. Such studies can aid our understanding of PNSP evolution and help improve the already highly-performing bioinformatic methods capable of identifying PNSP from genomic surveillance data.

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  • Accepted:
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Keyword(s): antibiotic resistance , genomic epidemiology , penicillin and pneumococcus
© 2019 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2019-10-01
2024-04-20
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Genomic epidemiology of penicillin-non-susceptible Streptococcus pneumoniae
M Gen 5, e000305 (2019); https://doi.org/10.1099/mgen.0.000305
/content/journal/mgen/10.1099/mgen.0.000305
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