RT Journal Article SR Electronic(1) A1 Gundogdu, Aycan A1 Nalbantoglu, UfukYR 2017 T1 Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases JF Microbial Genomics, VO 3 IS 4 OP SP e000112 DO https://doi.org/10.1099/mgen.0.000112 PB Microbiology Society, SN 2057-5858, AB A short while ago, the human genome and microbiome were analysed simultaneously for the first time as a multi-omic approach. The analyses of heterogeneous population cohorts showed that microbiome components were associated with human genome variations. In-depth analysis of these results reveals that the majority of those relationships are between immune pathways and autoimmune disease-associated microbiome components. Thus, it can be hypothesized that autoimmunity may be associated with homeostatic disequilibrium of the human-microbiome interactome. Further analysis of human genome–human microbiome relationships in disease contexts with tailored systems biology approaches may yield insights into disease pathogenesis and prognosis., UL https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000112