%0 Journal Article %A Gundogdu, Aycan %A Nalbantoglu, Ufuk %T Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases %D 2017 %J Microbial Genomics, %V 3 %N 4 %@ 2057-5858 %C e000112 %R https://doi.org/10.1099/mgen.0.000112 %K genome-microbiome interaction %K autoimmune disease %K metagenomics %I Microbiology Society, %X A short while ago, the human genome and microbiome were analysed simultaneously for the first time as a multi-omic approach. The analyses of heterogeneous population cohorts showed that microbiome components were associated with human genome variations. In-depth analysis of these results reveals that the majority of those relationships are between immune pathways and autoimmune disease-associated microbiome components. Thus, it can be hypothesized that autoimmunity may be associated with homeostatic disequilibrium of the human-microbiome interactome. Further analysis of human genome–human microbiome relationships in disease contexts with tailored systems biology approaches may yield insights into disease pathogenesis and prognosis. %U https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000112