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Volume 3, Issue 4

Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases Open Access

Abstract

A short while ago, the human genome and microbiome were analysed simultaneously for the first time as a multi-omic approach. The analyses of heterogeneous population cohorts showed that microbiome components were associated with human genome variations. In-depth analysis of these results reveals that the majority of those relationships are between immune pathways and autoimmune disease-associated microbiome components. Thus, it can be hypothesized that autoimmunity may be associated with homeostatic disequilibrium of the human-microbiome interactome. Further analysis of human genome–human microbiome relationships in disease contexts with tailored systems biology approaches may yield insights into disease pathogenesis and prognosis.

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  • Accepted:
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Keyword(s): autoimmune disease , genome-microbiome interaction and metagenomics
© 2017 The Authors
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2017-04-26
2023-12-09
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Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases
M Gen 3, e000112 (2017); https://doi.org/10.1099/mgen.0.000112
/content/journal/mgen/10.1099/mgen.0.000112
/content/journal/mgen/10.1099/mgen.0.000112
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