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Abstract

Introduction. We present what is believed to be the first report of candidaemia caused by Cyberlindnera (Pichia) jadinii (teleomorph of Candida utilis) in a patient with an aplastic anaemia.

Case presentation. The patient, a 21-year-old male, presented with hepatic cytolysis, cutaneous and pulmonary involvement, and septic shock. Cyberlindnera jadinii was identified by aerobic blood culture and MS. The patient initially received multiple and combined antifungal therapy, but continued to have persistent skin lesions and fever. He was successfully treated by emergency haploidentical haematopoietic stem cell transplantation, combined with triple antifungal therapy and supportive care.

Conclusion. Cyberlindnera jadinii, teleomorph of Candida utilis, which is not usually invasive, can lead to an opportunistic invasive infection in unhealthy adult patients. For treatment of the invasive candida infection, it is necessary to combine antifungal therapy and supportive care.

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2018-07-10
2020-01-24
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References

  1. Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T et al. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol 2016;172:187–207 [CrossRef][PubMed]
    [Google Scholar]
  2. Buerth C, Tielker D, Ernst JF. Candida utilis and Cyberlindnera (Pichia) jadinii: yeast relatives with expanding applications. Appl Microbiol Biotechnol 2016;100:6981–6990 [CrossRef][PubMed]
    [Google Scholar]
  3. Bougnoux ME, Gueho E, Potocka AC. Resolutive Candida utilis fungemia in a nonneutropenic patient. J Clin Microbiol 1993;31:1644–1645[PubMed]
    [Google Scholar]
  4. Lukić-Grlić A, Mlinarić-Missoni E, Skarić I, Vazić-Babić V, Svetec IK. Candida utilis candidaemia in neonatal patients. J Med Microbiol 2011;60:838–841 [CrossRef][PubMed]
    [Google Scholar]
  5. Hazen KC, Theisz GW, Howell SA. Chronic urinary tract infection due to Candida utilis. J Clin Microbiol 1999;37:824–827[PubMed]
    [Google Scholar]
  6. Alsina A, Mason M, Uphoff RA, Riggsby WS, Becker JM et al. Catheter-associated Candida utilis fungemia in a patient with acquired immunodeficiency syndrome: species verification with a molecular probe. J Clin Microbiol 1988;26:621–624[PubMed]
    [Google Scholar]
  7. Maziarz RT, Brazauskas R, Chen M, McLeod AA, Martino R et al. Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study. Bone Marrow Transplant 2017;52:270–278 [CrossRef][PubMed]
    [Google Scholar]
  8. Penack O, Tridello G, Hoek J, Socié G, Blaise D et al. Influence of pre-existing invasive aspergillosis on allo-HSCT outcome: a retrospective EBMT analysis by the infectious diseases and acute leukemia working parties. Bone Marrow Transplant 2016;51:418–423 [CrossRef][PubMed]
    [Google Scholar]
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