1887

Abstract

This is the first case report of septic abortion due to β-lactamase-negative ampicillin-resistant (BLNAR) non-typeable infection. In Japan, BLNAR is widespread and has become a clinical concern, especially in paediatrics and otolaryngology, but has not been previously recognized as a causative agent of obstetric or gynaecological infection.

A 31-year-old pregnant woman presented at 17 weeks and 6 days of gestation with a high fever; she was admitted with a diagnosis of threatened premature delivery. Despite tocolytic treatment, she aborted spontaneously 2 h after admission and then entered septic shock. BLNAR was detected in both blood and vaginal cultures. Her condition gradually improved after several days of treatment with cefotaxime, and she was ultimately discharged without sequelae or complaints.

Although penicillin with a β-lactamase inhibitor is currently recommended for the treatment of septic abortion, this combination will probably lead to treatment failure in the case of BLNAR infection. As this study reveals, can cause septic abortion; hence, future efforts should be undertaken to detect and therapeutically target this pathogen during pregnancy.

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2017-10-16
2020-01-22
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References

  1. Peltola H. Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clin Microbiol Rev 2000;13:302–317 [CrossRef][PubMed]
    [Google Scholar]
  2. Centers for Disease Control and Prevention (CDC) Progress toward elimination of Haemophilus influenzae type b disease among infants and children–United States, 1987–1995. MMWR Morb Mortal Wkly Rep 1996;45:901–906[PubMed]
    [Google Scholar]
  3. National Institute of Infectious Diseases Japan Effect of introduction of Hib vaccines and 7-valent pneumococcal conjugate vaccines (PCV7) on invasive bacterial infections: report of a study group (2008–2011). IASR Infect Agents Surveill Rep 2012;33:71–72
    [Google Scholar]
  4. Ladhani S, Slack MP, Heath PT, von Gottberg A, Chandra M et al. Invasive Haemophilus influenzae disease, Europe, 1996–2006. Emerg Infect Dis 2010;16:455–463 [CrossRef][PubMed]
    [Google Scholar]
  5. National Institute of Infectious Diseases Japan Invasive Haemophilus influenzae and Streptococcus pneumoniae infections, as of August 2014. IASR Infect Agents Surveill Rep 2014;35:229–230
    [Google Scholar]
  6. Kishii K, Chiba N, Morozumi M, Hamano-Hasegawa K, Ubukata K. Coincidence of Streptococcus pneumoniae or Haemophilus influenzae isolated simultaneously in epipharynx and middle-ear fluids in pediatric patients with acute otitis media. Jpn J Chemother 2009;57:76–81
    [Google Scholar]
  7. Shiro H, Sato Y, Toyonaga Y, Hanaki H, Sunakawa K. Nationwide survey of the development of drug resistance in the pediatric field in 2000–2001, 2004, 2007, 2010, and 2012: evaluation of the changes in drug sensitivity of Haemophilus influenzae and patients' background factors. J Infect Chemother 2015;21:247–256 [CrossRef][PubMed]
    [Google Scholar]
  8. Kakuta R, Yano H, Hidaka H, Kanamori H, Endo S et al. Molecular epidemiology of ampicillin-resistant Haemophilus influenzae causing acute otitis media in Japanese infants and young children. Pediatr Infect Dis J 2016;35:501–506 [CrossRef][PubMed]
    [Google Scholar]
  9. Royal College of Obstetricians and Gynaecologists Bacterial sepsis in pregnancy. www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg64a/ [accessed 12 May 2017]
  10. Eschenbach DA. Treating spontaneous and induced septic abortions. Obstet Gynecol 2015;125:1042–1048 [CrossRef][PubMed]
    [Google Scholar]
  11. Falla TJ, Crook DW, Brophy LN, Maskell D, Kroll JS et al. PCR for capsular typing of Haemophilus influenzae. J Clin Microbiol 1994;32:2382–2386[PubMed]
    [Google Scholar]
  12. Clinical and Laboratory Standards Institute Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, Approved Standard—10th ed. CLSI document M07-A10 Wayne, PA: Clinical and Laboratory Standards Institute; 2015
    [Google Scholar]
  13. Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial Susceptibility Testing, 27th ed. CLSI Supplement M100 Wayne, PA: Clinical and Laboratory Standards Institute; 2015
    [Google Scholar]
  14. Ubukata K, Shibasaki Y, Yamamoto K, Chiba N, Hasegawa K et al. Association of amino acid substitutions in penicillin-binding protein 3 with β-lactam resistance in β-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother 2001;45:1693–1699 [CrossRef][PubMed]
    [Google Scholar]
  15. Meats E, Feil EJ, Stringer S, Cody AJ, Goldstein R et al. Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing. J Clin Microbiol 2003;41:1623–1636 [CrossRef][PubMed]
    [Google Scholar]
  16. Leszczynski P, van Belkum A, Pituch H, Verbrugh H, Meisel-Mikolajczyk F. Vaginal carriage of enterotoxigenic Bacteroides fragilis in pregnant women. J Clin Microbiol 1997;35:2899–2903[PubMed]
    [Google Scholar]
  17. Wexler HM. Susceptibility testing of anaerobic bacteria: myth, magic, or method?. Clin Microbiol Rev 1991;4:470–484 [CrossRef][PubMed]
    [Google Scholar]
  18. Ishikawa K, Itou T, Suzuki K, Saitou J, Ikoma Y et al. Three cases of infections abortion or premature delivery caused by Haemophilus influenzae. Nihon Sanka Fujinka Gakkai Zasshi 2000;52:689–693
    [Google Scholar]
  19. Albritton WL, Brunton JL, Meier M, Bowman MN, Slaney LA. Haemophilus influenzae: comparison of respiratory tract isolates with genitourinary tract isolates. J Clin Microbiol 1982;16:826–831[PubMed]
    [Google Scholar]
  20. Martínez MA, Ovalle A, Ulloa MT, Vidal RM. Role of Haemophilus influenzae in intra-amniotic infection in patients with preterm rupture of membranes. Eur J Clin Microbiol Infect Dis 1999;18:890–892 [CrossRef][PubMed]
    [Google Scholar]
  21. National Institute of Infectious Diseases Japan Invasive Haemophilus influenzae and Streptococcus pneumoniae infections, as of August 2014. IASR Infect Agents Sureveill Rep 2014;35:229–230
    [Google Scholar]
  22. Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SE et al. The role of infection in miscarriage. Hum Reprod Update 2016;22:116–133 [CrossRef][PubMed]
    [Google Scholar]
  23. Puig C, Calatayud L, Martí S, Tubau F, Garcia-Vidal C et al. Molecular epidemiology of nontypeable Haemophilus influenzae causing community-acquired pneumonia in adults. PLoS One 2013;8:e82515 [CrossRef][PubMed]
    [Google Scholar]
  24. Giufrè M, Cardines R, Accogli M, Cerquetti M. Neonatal invasive Haemophilus influenzae disease and genotypic characterization of the associated strains in Italy. Clin Infect Dis 2015;61:1203–1204 [CrossRef][PubMed]
    [Google Scholar]
  25. Kilian M. A taxonomic study of the genus Haemophilus, with the proposal of a new species. J Gen Microbiol 1976;93:9–62 [CrossRef][PubMed]
    [Google Scholar]
  26. Quentin R, Martin C, Musser JM, Pasquier-Picard N, Goudeau A. Genetic characterization of a cryptic genospecies of Haemophilus causing urogenital and neonatal infections. J Clin Microbiol 1993;31:1111–1116[PubMed]
    [Google Scholar]
  27. Webster PB, Maher CF, Farrell DJ. Neonatal infection due to Haemophilus influenzae biotype IV. Aust N Z J Obstet Gynaecol 1995;35:102–103 [CrossRef][PubMed]
    [Google Scholar]
  28. Ito T, Shibata H, Nakazawa M, Myokai M, Ikegaya K et al. Meningitis and septicemia caused by nontypeable Haemophilus influenzae in a previously healthy 2-year-old girl. J Infect Chemother 2011;17:559–562 [CrossRef][PubMed]
    [Google Scholar]
  29. Kay SE, Nack Z, Jenner BM. Meningitis and septicaemia in a child caused by non-typable Haemophilus influenzae biotype III. Med J Aust 2001;175:484–485[PubMed]
    [Google Scholar]
  30. Calner PA, Salinas ML, Steck A, Schechter-Perkins E. Haemophilus influenzae sepsis and placental abruption in an unvaccinated immigrant. West J Emerg Med 2012;13:133–135 [CrossRef][PubMed]
    [Google Scholar]
  31. Cherpes TL, Kusne S, Hillier SL. Haemophilus influenzae septic abortion. Infect Dis Obstet Gynecol 2002;10:161–164 [CrossRef][PubMed]
    [Google Scholar]
  32. Osaki Y, Sanbongi Y, Ishikawa M, Kataoka H, Suzuki T et al. Genetic approach to study the relationship between penicillin-binding protein 3 mutations and Haemophilus influenzae β-lactam resistance by using site-directed mutagenesis and gene recombinants. Antimicrob Agents Chemother 2005;49:2834–2839 [CrossRef][PubMed]
    [Google Scholar]
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