1887

Abstract

is a small cell-wall-lacking bacterium that belongs to the mycoplasma (Mollicutes) prokaryote micro-organisms. It is a common cause of both upper and lower respiratory tract infections in all age groups. Respiratory illness is the most common manifestation of infection; however, extrapulmonary involvement may be present or predominant. The skin, mucus membranes, central nervous system, cardiovascular system, haematopoietic system, kidneys and musculoskeletal system are the most commonly involved extrapulmonary sites. Immune thrombocytopenia purpura has been reported as a rare haematological manifestation of mycoplasma infection. Here, we report, with a literature review, the case of a young adult with infection, presenting with acute febrile illness, myringitis, erythema multiforme, mild Raynaud’s phenomenon symptoms and severe thrombocytopenia.

Our patient was a 24-year-old healthy man who presented to an emergency department with acute febrile illness, upper respiratory tract infection symptoms, myringitis, erythema multiforme skin lesions, severe thrombocytopenia, and pale and cold hands. serology suggested acute infection. The patient had a complete resolution of symptoms and gradual recovery from the thrombocytopenia after a course of anti- therapy with azithromycin. Our case illustrates the multi-system involvement of infection.

is a frequent cause of upper and lower respiratory tract infections in children and young adults. Multi-system involvement including the skin, vascular and haematological systems in young adults with upper or lower respiratory tract infection, as in our patient, should raise the suspicion of infection. Our case also illustrates an excellent clinical response and recovery from thrombocytopenia shortly after anti- antimicrobial therapy.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.005117
2017-09-25
2024-12-06
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/4/9/jmmcr005117.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.005117&mimeType=html&fmt=ahah

References

  1. Bennett J, Dolin R, Blaser M, Mandell G, Douglas R et al. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th ed. Philadelphia, PA: Saunders;; 2015 pp. 2183–2189
    [Google Scholar]
  2. Eaton MD, van Herick W, Meiklejohn G. Studies on the etiology of primary atypical pneumonia: III. Specific neutralization of the virus by human serum. J Exp Med 1945; 82:329–342 [View Article][PubMed]
    [Google Scholar]
  3. Foy HM. Infections caused by Mycoplasma pneumoniae and possible carrier state in different populations of patients. Clin Infect Dis 1993; 17:S37–S46 [View Article][PubMed]
    [Google Scholar]
  4. Heymann DL. Control of Communicable Diseases Manual Washington, DC: American Public Health Association; 2015 [Crossref]
    [Google Scholar]
  5. Narita M. Classification of extrapulmonary manifestations due to Mycoplasma pneumoniae infection on the basis of possible pathogenesis. Front Microbiol 2016; 7:23 [View Article][PubMed]
    [Google Scholar]
  6. Schalock PC, Dinulos JG. Mycoplasma pneumoniae-induced cutaneous disease. Int J Dermatol 2009; 48:673–681 [View Article][PubMed]
    [Google Scholar]
  7. Jacobs E. Serological diagnosis of Mycoplasma pneumoniae infections: a critical review of current procedures. Clin Infect Dis 1993; 17:S79–S82 [View Article][PubMed]
    [Google Scholar]
  8. Räty R, Rönkkö E, Kleemola M. Sample type is crucial to the diagnosis of Mycoplasma pneumoniae pneumonia by PCR. J Med Microbiol 2005; 54:287–291 [View Article][PubMed]
    [Google Scholar]
  9. Roberts DB. The etiology of bullous myringitis and the role of mycoplasmas in ear disease: a review. Pediatrics 1980; 65:761–766[PubMed]
    [Google Scholar]
  10. Murray HW, Masur H, Senterfit LB, Roberts RB. The protean manifestations of Mycoplasma pneumoniae infection in adults. Am J Med 1975; 58:229–242 [View Article][PubMed]
    [Google Scholar]
  11. Ferwerda A, Moll HA, de Groot R. Respiratory tract infections by Mycoplasma pneumoniae in children: a review of diagnostic and therapeutic measures. Eur J Pediatr 2001; 160:483–491 [View Article][PubMed]
    [Google Scholar]
  12. Aviner S, Miskin H, London D, Horowitz S, Schlesinger M. Mycoplasma pneumonia infection: a possible trigger for immune thrombocytopenia. Indian J Hematol Blood Transfus 2011; 27:46–50 [View Article][PubMed]
    [Google Scholar]
  13. Biberfeld G, Norberg R. Circulating immune complexes in Mycoplasma pneumoniae infection. J Immunol 1974; 112:413–415[PubMed]
    [Google Scholar]
  14. Feizi T, Taylor-Robinson D. Cold agglutinin anti-I and Mycoplasma pneumoniae . Immunology 1967; 13:405–409[PubMed]
    [Google Scholar]
/content/journal/jmmcr/10.1099/jmmcr.0.005117
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.005117
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error