sternal wound infection treated with ceftaroline: case report and literature review Open Access

Abstract

Case reports have emerged with identification of infections including sternal wound infections and foreign bodies such as central lines and shunts.

We present a case that demonstrates the need to consider infection as a cause of sternal wound infection and highlights the utility of novel diagnostics to aid in the identification of unusual pathogens that can cause post-operative infections. We report here the first successful use of ceftaroline for treatment of a sternal wound infection.

There are only case reports and assays to date to guide treatment of this infection, and we now add ceftaroline as a new drug to consider, though adequate surgical debridement is paramount.

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/content/journal/jmmcr/10.1099/jmmcr.0.005113
2017-09-25
2024-03-29
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References

  1. Filsoufi F, Castillo JG, Rahmanian PB, Broumand SR, Silvay G et al. Epidemiology of deep sternal wound infection in cardiac surgery. J Cardiothorac Vasc Anesth 2009; 23:488–494 [View Article][PubMed]
    [Google Scholar]
  2. Kubota H, Miyata H, Motomura N, Ono M, Takamoto S et al. Deep sternal wound infection after cardiac surgery. J Cardiothorac Surg 2013; 8:1 [View Article]
    [Google Scholar]
  3. Lemaignen A, Birgand G, Ghodhbane W, Alkhoder S, Lolom I et al. Sternal wound infection after cardiac surgery: incidence and risk factors according to clinical presentation. Clin Microbiol Infect 2015; 21:674.e11–674674 [View Article][PubMed]
    [Google Scholar]
  4. Sajja LR. Strategies to reduce deep sternal wound infection after bilateral internal mammary artery grafting. Int J Surg 2015; 16:171–178 [View Article][PubMed]
    [Google Scholar]
  5. Richet HM, Craven PC, Brown JM, Lasker BA, Cox CD et al. A cluster of Rhodococcus (Gordona) bronchialis sternal-wound infections after coronary-artery bypass surgery. N Engl J Med 1991; 324:104–109 [View Article][PubMed]
    [Google Scholar]
  6. Blaschke AJ, Bender J, Byington CL, Korgenski K, Daly J et al. Gordonia species: emerging pathogens in pediatric patients that are identified by 16S ribosomal RNA gene sequencing. Clin Infect Dis 2007; 45:483–486 [View Article][PubMed]
    [Google Scholar]
  7. Si D, Rajmokan M, Lakhan P, Marquess J, Coulter C et al. Surgical site infections following coronary artery bypass graft procedures: 10 years of surveillance data. BMC Infect Dis 2014; 14:1 [View Article][PubMed]
    [Google Scholar]
  8. Wright SN, Gerry JS, Busowski MT, Klochko AY, McNulty SG et al. Gordonia bronchialis sternal wound infection in 3 patients following open heart surgery: intraoperative transmission from a healthcare worker. Infect Control Hosp Epidemiol 2012; 33:1238–1241 [View Article][PubMed]
    [Google Scholar]
  9. Aoyama K, Kang Y, Yazawa K, Gonoi T, Kamei K et al. Characterization of clinical isolates of Gordonia species in Japanese clinical samples during 1998–2008. Mycopathologia 2009; 168:175–183 [View Article][PubMed]
    [Google Scholar]
  10. Lin JC, Aung G, Thomas A, Jahng M, Johns S et al. The use of ceftaroline fosamil in methicillin-resistant Staphylococcus aureus endocarditis and deep-seated MRSA infections: a retrospective case series of 10 patients. J Infect Chemother 2013; 19:42–49 [View Article][PubMed]
    [Google Scholar]
  11. Rodriguez-Lozano J, Pérez-Llantada E, Agüero J, Rodríguez-Fernández A, Ruiz de Alegria C et al. Sternal wound infection caused by Gordonia bronchialis: identification by MALDI-TOF MS. JMM Case Rep 2016; 3:e005067 [View Article]
    [Google Scholar]
  12. Bartolomé-Álvarez J, Sáez-Nieto JA, Escudero-Jiménez A, Barba-Rodríguez N, Galán-Ros J et al. Cutaneous abscess due to Gordonia bronchialis: case report and literature review. Rev Esp Quimioter 2016; 29:170–173[PubMed]
    [Google Scholar]
  13. Lam JY, Wu AK, Leung WS, Cheung I, Tsang CC et al. Gordonia species as emerging causes of continuous-ambulatory-peritoneal-dialysis-related peritonitis identified by 16S rRNA and secA1 gene sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). J Clin Microbiol 2015; 53:671–676 [View Article][PubMed]
    [Google Scholar]
  14. Ma TK, Chow KM, Kwan BC, Lee KP, Leung CB et al. Peritoneal-dialysis related peritonitis caused by Gordonia species: report of four cases and literature review. Nephrology 2014; 19:379–383 [View Article][PubMed]
    [Google Scholar]
  15. Nguyen DB, Gupta N, Abou-Daoud A, Klekamp BG, Rhone C et al. A polymicrobial outbreak of surgical site infections following cardiac surgery at a community hospital in Florida, 2011–2012. Am J Infect Control 2014; 42:432–435 [View Article][PubMed]
    [Google Scholar]
  16. Chang JH, Ji M, Hong HL, Choi SH, Kim YS et al. Sternal osteomyelitis caused by Gordonia bronchialis after open-heart surgery. Infect Chemother 2014; 46:110 [View Article][PubMed]
    [Google Scholar]
  17. Vasquez MA, Marne C, Villuendas MC, Arazo P. Subacute sternal osteomyelitis caused by Gordonia bronchialis after open-heart surgery. Enferm Infecc Microbiol Clin 2013; 31:559–560 [View Article][PubMed]
    [Google Scholar]
  18. Siddiqui N, Toumeh A, Georgescu C. Tibial osteomyelitis caused by Gordonia bronchialis in an immunocompetent patient. J Clin Microbiol 2012; 50:3119–3121 [View Article][PubMed]
    [Google Scholar]
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