1887

Abstract

Introduction. Case reports have emerged with identification of Gordonia bronchialis infections including sternal wound infections and foreign bodies such as central lines and shunts.

Case presentation. We present a case that demonstrates the need to consider Gordonia infection as a cause of sternal wound infection and highlights the utility of novel diagnostics to aid in the identification of unusual pathogens that can cause post-operative infections. We report here the first successful use of ceftaroline for treatment of a G. bronchialis sternal wound infection.

Conclusion. There are only case reports and in vitro assays to date to guide treatment of this infection, and we now add ceftaroline as a new drug to consider, though adequate surgical debridement is paramount.

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2017-09-13
2019-10-15
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References

  1. Filsoufi F, Castillo JG, Rahmanian PB, Broumand SR, Silvay G et al. Epidemiology of deep sternal wound infection in cardiac surgery. J Cardiothorac Vasc Anesth 2009;23:488–494 [CrossRef][PubMed]
    [Google Scholar]
  2. Kubota H, Miyata H, Motomura N, Ono M, Takamoto S et al. Deep sternal wound infection after cardiac surgery. J Cardiothorac Surg 2013;8:1 [CrossRef]
    [Google Scholar]
  3. Lemaignen A, Birgand G, Ghodhbane W, Alkhoder S, Lolom I et al. Sternal wound infection after cardiac surgery: incidence and risk factors according to clinical presentation. Clin Microbiol Infect 2015;21:674.e11–674674 [CrossRef][PubMed]
    [Google Scholar]
  4. Sajja LR. Strategies to reduce deep sternal wound infection after bilateral internal mammary artery grafting. Int J Surg 2015;16:171–178 [CrossRef][PubMed]
    [Google Scholar]
  5. Richet HM, Craven PC, Brown JM, Lasker BA, Cox CD et al. A cluster of Rhodococcus (Gordona) bronchialis sternal-wound infections after coronary-artery bypass surgery. N Engl J Med 1991;324:104–109 [CrossRef][PubMed]
    [Google Scholar]
  6. Blaschke AJ, Bender J, Byington CL, Korgenski K, Daly J et al. Gordonia species: emerging pathogens in pediatric patients that are identified by 16S ribosomal RNA gene sequencing. Clin Infect Dis 2007;45:483–486 [CrossRef][PubMed]
    [Google Scholar]
  7. Si D, Rajmokan M, Lakhan P, Marquess J, Coulter C et al. Surgical site infections following coronary artery bypass graft procedures: 10 years of surveillance data. BMC Infect Dis 2014;14:1 [CrossRef][PubMed]
    [Google Scholar]
  8. Wright SN, Gerry JS, Busowski MT, Klochko AY, McNulty SG et al. Gordonia bronchialis sternal wound infection in 3 patients following open heart surgery: intraoperative transmission from a healthcare worker. Infect Control Hosp Epidemiol 2012;33:1238–1241 [CrossRef][PubMed]
    [Google Scholar]
  9. Aoyama K, Kang Y, Yazawa K, Gonoi T, Kamei K et al. Characterization of clinical isolates of Gordonia species in Japanese clinical samples during 1998–2008. Mycopathologia 2009;168:175–183 [CrossRef][PubMed]
    [Google Scholar]
  10. Lin JC, Aung G, Thomas A, Jahng M, Johns S et al. The use of ceftaroline fosamil in methicillin-resistant Staphylococcus aureus endocarditis and deep-seated MRSA infections: a retrospective case series of 10 patients. J Infect Chemother 2013;19:42–49 [CrossRef][PubMed]
    [Google Scholar]
  11. Rodriguez-Lozano J, Pérez-Llantada E, Agüero J, Rodríguez-Fernández A, Ruiz de Alegria C et al. Sternal wound infection caused by Gordonia bronchialis: identification by MALDI-TOF MS. JMM Case Rep 2016;3:e005067 [CrossRef]
    [Google Scholar]
  12. Bartolomé-Álvarez J, Sáez-Nieto JA, Escudero-Jiménez A, Barba-Rodríguez N, Galán-Ros J et al. Cutaneous abscess due to Gordonia bronchialis: case report and literature review. Rev Esp Quimioter 2016;29:170–173[PubMed]
    [Google Scholar]
  13. Lam JY, Wu AK, Leung WS, Cheung I, Tsang CC et al. Gordonia species as emerging causes of continuous-ambulatory-peritoneal-dialysis-related peritonitis identified by 16S rRNA and secA1 gene sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). J Clin Microbiol 2015;53:671–676 [CrossRef][PubMed]
    [Google Scholar]
  14. Ma TK, Chow KM, Kwan BC, Lee KP, Leung CB et al. Peritoneal-dialysis related peritonitis caused by Gordonia species: report of four cases and literature review. Nephrology 2014;19:379–383 [CrossRef][PubMed]
    [Google Scholar]
  15. Nguyen DB, Gupta N, Abou-Daoud A, Klekamp BG, Rhone C et al. A polymicrobial outbreak of surgical site infections following cardiac surgery at a community hospital in Florida, 2011–2012. Am J Infect Control 2014;42:432–435 [CrossRef][PubMed]
    [Google Scholar]
  16. Chang JH, Ji M, Hong HL, Choi SH, Kim YS et al. Sternal osteomyelitis caused by Gordonia bronchialis after open-heart surgery. Infect Chemother 2014;46:110 [CrossRef][PubMed]
    [Google Scholar]
  17. Vasquez MA, Marne C, Villuendas MC, Arazo P. Subacute sternal osteomyelitis caused by Gordonia bronchialis after open-heart surgery. Enferm Infecc Microbiol Clin 2013;31:559–560 [CrossRef][PubMed]
    [Google Scholar]
  18. Siddiqui N, Toumeh A, Georgescu C. Tibial osteomyelitis caused by Gordonia bronchialis in an immunocompetent patient. J Clin Microbiol 2012;50:3119–3121 [CrossRef][PubMed]
    [Google Scholar]
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