1887

JMM Case Reports

Volume 3, Issue 4

Fatal case of co-infection with dengue virus and during a dengue epidemic in the state of Rio de Janeiro, Brazil Open Access

Abstract

Introduction:

Dengue and meningococcal disease are caused by two different agents: a flavivirus and a Gram-negative bacterium, respectively. The first symptoms of both diseases can be indistinct and a rapid and accurate diagnosis is crucial, considering that both diseases are associated with high morbidity and mortality, representing a major public-health problem in Brazil.

Case presentation:

We report a fatal case of co-infection of dengue virus (DENV) and in a 54-year-old patient. The serum tested positive for DENV NS1 antigen, and serogroup C was detected by -PCR. Following the initial positive result for DENV infection, rRT-PCRwas performed and DENV-4 was confirmed.

Conclusion:

Our report highlights the importance of accurate differential diagnosis during periods of high circulation of DENV, in order to provide adequate management and an improved outcome.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Dengue , diagnostic , meningococcal disease , PCR and RT-PCR
© 2016 The Authors
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2016-07-11
2023-03-20
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References

  1. Brasil, Ministério da Saúde. SVS/MS 2015; Perfil Epidemiológico da Meningite Brasil & Mundo. http://www.saude.rs.gov.br/upload/1437759444_Perfil%20Epidemiol%C3%B3gico%20da%20Meningite%20Brasil%20&%20Mundo.pdf Accessed on 25 May 2016
  2. Brasil Ministério da Saúde SVS/MS 2016; Informe epidemiológico da dengue – casos de dengue no Brasil, 1990 a 2014. http://portalsaude.saude.gov.br/images/pdf/2015/julho/29/Dengue-at---2014.pdf Accessed on 19 May 2016
  3. Coureuil M., Join-Lambert O., Lécuyer H., Bourdoulous S., Marullo S., Nassif X. 2013; Pathogenesis of meningococcemia. Cold Spring Harb Perspect Med 3:a012393 [View Article][PubMed]
     [Google Scholar]
  4. de Filippis I., do Nascimento C. R., Clementino M. B., Sereno A. B., Rebelo C., Souza N. N., Riley L. W. 2005; Rapid detection of Neisseria meningitidis in cerebrospinal fluid by one-step polymerase chain reaction of the nspA gene. Diagn Microbiol Infect Dis 51:85–90 [CrossRef]
     [Google Scholar]
  5. Gasparini R., Amicizia D., Lai P. L., Panatto D. 2012; Neisseria meningitidis, pathogenetic mechanisms to overcome the human immune defences. J Prev Med Hyg 53:50–55[PubMed]
     [Google Scholar]
  6. Gorla M. C., de Paiva M. V., Salgueiro V. C., Lemos A. P., Brandão A. P., Vázquez J. A., Brandileone M. C. 2011; Antimicrobial susceptibility of Neisseria meningitidis strains isolated from meningitis cases in Brazil from 2006 to 2008. Enferm Infecc Microbiol Clin 29:85–89 [View Article][PubMed]
     [Google Scholar]
  7. Lanciotti R. S., Calisher C. H., Gubler D. J., Chang G. J., Vorndam A. V. 1992; Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30:545–551[PubMed]
     [Google Scholar]
  8. Nagassar R. P., Bridgelal-Nagassar R. J., McMorris N., Roye-Green K. J. 2012; Staphylococcus aureus pneumonia and dengue virus co-infection and review of implications of coinfection. BMJ Case Rep 2012:bcr0220125804
     [Google Scholar]
  9. Pérez Rodríguez N. M., Galloway R., Blau D. M., Traxler R., Bhatnagar J., Zaki S. R., Rivera A., Torres J. V., Noyd D. et al. 2014; Case series of fatal Leptospira spp./dengue virus co-infections-Puerto Rico, 2010-2012. AmJ Trop Med Hyg 91:760–765 [View Article]
     [Google Scholar]
  10. Siqueira J. B.,. Jr, Martelli C. M., Coelho G. E., Simplicio A. C., Hatch D. L. 2005; Dengue and dengue hemorrhagic fever, Brazil, 1981-2002. Emerg Infect Dis 11:48–53 [View Article][PubMed]
     [Google Scholar]
  11. Srirangaraj S., Kali A., Vijayan S. 2014; Dengue co-infection in a blood stream infection caused by Stenotrophomonas maltophilia: a case report. Australas Med J 7:441–444 [View Article][PubMed]
     [Google Scholar]
  12. Stephens D. S., Greenwood B., Brandtzaeg P. 2007; Epidemic meningitis, meningococcaemia, and Neisseria meningitidis . Lancet 369:2196–2210 [View Article][PubMed]
     [Google Scholar]
  13. SVS/SES-RJ 2016; Boletim Epidemiológico 004/2016. Governo do Estado do Rio de Janeiro. http://riocomsaude.rj.gov.br/Publico/MostrarArquivo.aspx?C=DmjDDb%2BR24E%3D Accessed on 25 May 2016
  14. Tsai J. J., Hsieh M. H., Liu L. T., Hsiao H. M., Perng G. C. 2013; Mortality from septic shock in a dengue infected patient: a case report. Southeast Asian J Trop Med Public Health 44:623–629[PubMed]
     [Google Scholar]
  15. Tzanakaki G., Tsolia M., Vlachou V., Theodoridou M., Pangalis A., Foustoukou M., Karpathios T., Blackwell C. C., Kremastinou J. 2003; Evaluation of non-culture diagnosis of invasive meningococcal disease by polymerase chain reaction (PCR). FEMS Immunol Med Microbiol 39:31–36 [View Article][PubMed]
     [Google Scholar]
  16. van Panhuis W. G., Hyun S., Blaney K., Marques E. T. A. Jr, Coelho G. E., Siqueira J. B., Tibshirani R., da Silva J. B. Jr, Rosenfeld R. 2014; Risk of dengue for tourists and teams during the World Cup 2014 in Brazil. PLoS Negl Trop Dis 8:e3063 [View Article][PubMed]
     [Google Scholar]
  17. Varon J., Chen K., Sternbach G. L. 1998; Rupert Waterhouse and Carl Friderichsen: adrenal apoplexy. J Emerg Med 16:643–647 [View Article][PubMed]
     [Google Scholar]
  18. Zambrano B., San Martin J. L. 2014; Epidemiology of dengue in Latin America. J Pediatric Infect Dis Soc 3:181–182 [View Article][PubMed]
     [Google Scholar]
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