1887

Abstract

Introduction:

species have a worldwide distribution and are commonly found as saprophytes of soil or water. However, they can cause human disease especially in immunocompromised patients, with respiratory infection being the most frequent clinical manifestation of the disease. The aim of the present work was to describe the first clinical isolation of from the sputum of a patient from the north of Spain suspected of having tuberculosis.

Case Presentation:

In November 2012, a chest X-ray showed a mass in the left upper lobe of the lung of a 75-year-old man with persistent cough with bloody expectoration. The patient was sent to the outpatient pulmonology consultation for further studies. In the sputum sent for mycobacterial study, a isolate was present that was identified by sequencing a 1440 bp fragment of the 16S rRNA gene as at the Special Bacteriology Reference Laboratory at the Centers for Disease Control and Prevention (USA).

Conclusion:

The clinical significance of in the sputum of this patient was uncertain, as symptoms of persistent cough with haemoptysis in the absence of other identified causes suggested the possible involvement of in a bronchial lung infection. However, the spontaneous resolution of symptoms without specific antimicrobial treatment pointed to the possibility of a transient colonization. To the best of our knowledge, this is the first evidence in the literature of the isolation of in humans.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.005022
2016-03-24
2019-10-18
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/3/2/jmmcr005022.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.005022&mimeType=html&fmt=ahah

References

  1. Albuquerque de Barros E. V. S. , Manfio G. P. , RibieroMaitan V. , Mendes Bataus L. A. , Kim S. B. , Maldonado L. A. , Goodfellow M. . 2003; Nocardia cerradoensis sp. nov., a novel isolate from Cerrado soil in Brazil. Int J Syst Evol Microbiol 53: 29– 33 [CrossRef] [PubMed]
    [Google Scholar]
  2. Ambrosioni J. , Lew D. , Garbino J. . 2010; Nocardiosis: updated clinical review and experience at a tertiary center. Infection 38: 89– 97 [CrossRef] [PubMed]
    [Google Scholar]
  3. Brown-Elliott B. A. , Brown J. M. , Conville P. S. , Wallace R.J., Jr . 2006; Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy. Clin Microbiol Rev 19: 259– 282 [CrossRef] [PubMed]
    [Google Scholar]
  4. Clarridge J.E., III . 2004; Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. Clin Microbiol Rev 17: 840– 862 [CrossRef] [PubMed]
    [Google Scholar]
  5. CLSI 2008; Interpretive Criteria for the Identification of Bacteria and Fungi by DNA Target Sequencing ; Approved Guideline MM18-A Wayne, PA: Clinical and Laboratory Standards Institute;
    [Google Scholar]
  6. CLSI 2011; Susceptibility Testing of Nycobacteria, Nocardiae, and other Aerobic Actinomycetes ; Approved Standard M24-A Wayne, PA: Clinical and Laboratory Standards Institute;
    [Google Scholar]
  7. Filice G. A. . 2005; Nocardiosis in persons with human immunodeficiency virus infection, transplant recipients, and large, geographically defined populations. J Lab Clin Med 145: 156– 162 [CrossRef] [PubMed]
    [Google Scholar]
  8. Jannat-Khah D. , Kroppenstedt R. M. , Klenk H. P. , Spröer C. , Schumann P. , Lasker B. A. , Steigerwalt A. G. , Hinrikson H. P. , Brown J. M. . 2010; Nocardia mikamii sp. nov., isolated from human pulmonary infections in the USA. Int J Syst Evol Microbiol 60: 2272– 2276 [CrossRef] [PubMed]
    [Google Scholar]
  9. Kämpfer P. , Lodders N. , Grün-Wollny I. , Martin K. , Busse H. J. . 2012; Nocardia grenadensis sp. nov., isolated from sand of the Caribbean Sea. Int J Syst Evol Microbiol 62: 693– 697 [CrossRef] [PubMed]
    [Google Scholar]
  10. Lasker B. A. , Moser B. D. , Brown J. M. . 2011; Gordonia. . In Molecular Detection of Human Bacterial Pathogens, pp. 95– 110. Edited by Liu D. . Boca Raton, FL: CRC Taylor & Francis; [CrossRef]
    [Google Scholar]
  11. McTaggart L. R. , Richardson S. E. , Witkowska M. , Zhang S. X. . 2010; Phylogeny and identification of Nocardia species on the basis of multilocus sequence analysis. J Clin Microbiol 48: 4525– 4533 [CrossRef] [PubMed]
    [Google Scholar]
  12. Mukesh S. . 2014; Actinomycetes: source, identification, and their applications. Int J Curr Microbiol App Sci 3: 801– 832
    [Google Scholar]
  13. Wilson M. . 2013;).http://d2oqb2vjj999su.cloudfront.net/users/000/080/532/579/attachments/UNCA%20Undergrad%20Research%20Paper.pdf Isolation and identification of antimicrobial-producing microbes from soil associated with an eastern Hemlock in the Great Smoky Mountains National Park. UNC Asheville J Undergrad Res http://d2oqb2vjj999su.cloudfront.net/users/000/080/532/579/attachments/UNCA%20Undergrad%20Research%20Paper.pdf
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.005022
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error