%0 Journal Article %A Rukumani, Devi V. %A Kamar, Azanna A. %A Ardita, Dewi R. %A Nee, Tang S. %A Yusof, Yasim M. %A Sekaran, Shamala D. %A Shankar, Esaki M. %T Recalcitrant coagulase‐negative methicillin‐sensitive Staphylococcus aureus in an extremely low‐birth‐weight pre‐term infant with thrombocytopaenia %D 2014 %J JMM Case Reports, %V 1 %N 3 %@ 2053-3721 %C e004242 %R https://doi.org/10.1099/jmmcr.0.004242 %K coagulase negative %K 16S rRNA gene sequencing %K neonatal infections %K sepsis %I Microbiology Society, %X Introduction: Infections due to Staphylococcus aureus are cumbersome to treat and control. Virulent S. aureus is commonly coagulase positive, whilst non‐virulent isolates are coagulase negative. Literature on coagulase‐negative variants of S. aureus and their role in clinical disease in neonates is seldom available. Case presentation: We report a case of an extremely low‐birth‐weight pre‐term infant who had persistent recalcitrant infection with coagulase‐negative methicillin‐sensitive S. aureus, which resulted in clinical sepsis, thrombocytopaenia and persistence in blood cultures for 7 weeks. The API STAPH‐Ident system (Bio‐Merieux) and 16S rRNA gene sequencing were used to confirm identity. Parallel use of blood culture yielded an isolate with the same phenotypic identity. Conclusion: Prompt identification of uncommon phenotypes of S. aureus also requires the use of appropriate molecular diagnostics to necessitate timely treatment of life‐threatening systemic infections in neonates. %U https://www.microbiologyresearch.org/content/journal/jmmcr/10.1099/jmmcr.0.004242