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Abstract

Introduction:

Disseminated fusariosis is a devastating disease in severely immunocompromised patients and is associated with high lethality.

Case presentation:

We describe a patient with severe disseminated fusariosis presenting initially as tonsillitis. was isolated from cultures of the tonsils, skin and blood, while histological evidence for fungal tissue invasion was detected in tissue samples of the tonsils, tongue, oesophagus, lungs, myocardium, intestine, kidney, mediastinal lymphnodes and skin. Susceptibility testing revealed resistance to voriconazole, posaconazole and caspofungin, and susceptibility to amphotericin B. The patient died, despite treatment with amphotericin B, due to multiorgan failure and refractory cardiac arrhythmia.

Conclusion:

Tonsillitis was the primary clinical manifestation of disseminated fatal fusariosis in this immunocompromised patient. It is important to know the spectrum of primary manifestations of less commonly encountered moulds in order to guide clinical decisions and early targeted therapy.

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2014-09-01
2019-11-13
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