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This report presents two cases of Fusobacterium bacteraemia associated with portal vein thrombosis. A 63‐year‐old man with a history of hypercholesterolaemia and nephrolithiasis was admitted to the hospital with fever and abdominal pain. A computed tomography (CT) scan revealed thrombosis of the posterior right portal vein. Blood cultures were positive for Fusobacterium nucleatum. The second case was a 53‐year‐old man with alcoholic steatohepatitis admitted with fever, chills and abdominal pain. A CT scan revealed right portal vein thrombosis and Fusobacterium necrophorum was isolated from his blood cultures. Both patients were successfully treated with intravenous ertapenem 1 g day–1 for 4 weeks with resolution of symptoms. These case reports underscore the importance of considering the diagnosis of portal vein thrombosis in patients with Fusobacterium bacteraemia of unclear aetiology.
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