1887

Abstract

Introduction:

The global incidence of diphtheria remained steady during 2007–2011 after a steady decline of over 95 % from 1980 to 2006. This was largely due to a resurgence of the disease in India, which alone accounted for 71–83 % of the total cases reported worldwide.

Case presentation:

This article describes the identification of an outbreak of diphtheria in two very remote villages of northern Karnataka in South India in May 2011 and detection of further cases in as many as seven nearby villages in the 6 months that followed, which resulted in at least three deaths. The ineffectiveness of the Universal Immunization Programme in its present form in reaching the remote villages is highlighted, and one case of diphtheria with a non‐toxigenic strain of , which is very rare in India and has the potential to upset eradication strategies, is documented.

Conclusion:

This article should provide a wake‐up call for the health administrators for restructuring and strengthening immunization strategies and programmes.

Keyword(s): children , diphtheria and outbreak
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2014-09-01
2019-11-17
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References

  1. CBHI( 2011;). Central Bureau of Health Intelligence, Directorate General of Health Services, Government of India. National Health Profiles New Delhi: Central Bureau of Health Intelligence.;http://cbhidghs.nic.in/index1.asp?linkid = 267 (Accessed 1 September 2012.)
    [Google Scholar]
  2. CBHI( 2012;). Central Bureau of Health Intelligence, Directorate General of Health Services, Government of India . National Health Profiles New Delhi: Central Bureau of Health Intelligence.;http://cbhidghs.nic.in/index2.asp?slid = 1256&sublinkid = 1163 (Accessed 7 May 2013.)
    [Google Scholar]
  3. Dravid M.N., Joshi S.A.. ( 2008;). Resurgence of diphtheria in Malegaon and Dhule regions of North Maharashtra. Indian J Med Res127:616–617
    [Google Scholar]
  4. Nakao H., Popovic T.. ( 1997;). Development of a direct PCR assay for detection of the diphtheria toxin gene. J Clin Microbiol 35 , 1651–1655
    [Google Scholar]
  5. Nath B., Mahanta T.G.. ( 2010;). Investigation of an outbreak of diphtheria in Borborooah Block of Dibrugarh District, Assam. Indian J Community Med35:436–438[CrossRef]
    [Google Scholar]
  6. Sashikala P., Reddy P.V., Prashanth K., Kanungo R., Devi S., Anitha P., Rajarajeshweri N., Cherian T.M.. ( 2011;). Persistence of non‐toxigenic Corynebacterium diphtheriae biotype Gravis strains in Pondicherry, southern India. J Clin Microbiol49:763[CrossRef]
    [Google Scholar]
  7. Sharma N.C., Banavaliker J.N., Ranjan R., Kumar R.. ( 2007;). Bacteriological and epidemiological characteristics of diphtheria in and around Delhi – a retrospective study. Indian J Med Res126:545–552
    [Google Scholar]
  8. WHO( 2012;). Immunization Surveillance, Assessment and Monitoring: Data, Statistics and Graphics. Geneva, Switzerland World Health Organization; Available at:http://www.who.int/entity/immunization_monitoring/data/incidence_series.xls Accessed 1 September 2012
    [Google Scholar]
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