1887

Abstract

Introduction:

Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes. is one of the most common and dangerous neurotropic fungi, able to cause brain abscess and disseminated infection.

Case Presentation:

We report a new case of phaeohyphomycosis brain abscesses caused by in Slovakia. The patient was a 63‐year‐old man having undergone heart transplantation, with dyspnoea, left‐sided bronchopneumonia and fevers. CT (computed tomography) and MRI (magnetic resonance imaging) of the brain revealed numerous abscesses. Bacterial infection was proven by neither the growth of bacteria in culture nor the presence of bacterial antigens. Direct microscopy of the pus from the brain abscess showed Gram‐positive hyphae. The isolate was finally identified as based on morphological and physiological features, and on DNA sequence analysis.

Conclusion:

In spite of appropriate therapy, neurological complications and accelerated respiratory insufficiency resulted in the patient’s death. Concerning clinical manifestation of the brain phaeohyphomycosis that can sometimes be a problem to distinguish from malignancy, physicians should also assume infection caused by this serious pathogen.

  • This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/).
Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.002659
2014-12-01
2024-12-09
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/1/4/jmmcr002659.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.002659&mimeType=html&fmt=ahah

References

  1. Aher A., Rastogi V. ( 2012). A case of cerebral abscess due to Cladophialophora bantiana . J Microbiol Infect Dis 2:171–173
    [Google Scholar]
  2. Ajantha G.S., Kulkarni R.D. ( 2011). Cladophialophora bantiana, the neurotropic fungus – a mini review. J Clin Diagn Res 5:1301–1306
    [Google Scholar]
  3. Banerjee T.K., Patwari A.K., Dutta R., Anand V.K., Chabra A. ( 2002). Cladosporium bantianum meningitis in a neonate. Indian J Pediatrics 69:721–723 [CrossRef]
    [Google Scholar]
  4. Fujita S.I., Senda Y., Nakaguchi S., Hashimoto T. ( 2001). Multiplex PCR using internal transcribed spacer 1 and 2 regions for rapid detection and identification of the yeast strains. J Clin Microbiol 39:3617–3622 [CrossRef]
    [Google Scholar]
  5. George I.A., Mathews M.S., Karthik R., John L., Sundar A., Abraham O.C., Joseph V. ( 2008). Fatal cerebral abscess caused by Cladophialophora bantiana . J Assoc Physicians India 56:470–472
    [Google Scholar]
  6. Huang W.M., Fan Y.M., Li W., Yang W.W. ( 2011). Brain abscess caused by Cladophialophora bantiana in China. J Med Microbiol 60:1872–1874 [CrossRef]
    [Google Scholar]
  7. Jurjevic Z., Li C., Dobranic J. ( 2013). First finding of Cladophialophora bantiana from the indoor environment in the United States. In Abstracts of the American Industrial Hygeine Conference & Exposition, Montréal, Canada
    [Google Scholar]
  8. Levin T.P., Baty D.E., Fekete T., Truant A.L., Suh B. ( 2004). Cladophialophora bantiana brain abscess in a solid‐organ transplant recipient: case report and review of the literature. J Clin Microbiol 42:4374–4378 [CrossRef]
    [Google Scholar]
  9. Li D.M., de Hoog G.S. ( 2009). Cerebral phaeohyphomycosis ‐ a cure at what lengths?. Lancet Infect Dis 9:376–383 [CrossRef]
    [Google Scholar]
  10. Martínez‐Lamas L., Alvarez M., Llovo J., Gené J., Cano J. ( 2013). Phaeohyphomycosis caused by Cladophialophora bantiana . Rev Iberoam Micol [Epub ahead of print]
    [Google Scholar]
  11. Revankar S.G. ( 2011). Cladophialophora bantiana brain abscess in an immunocompetent patient. Can J Infect Dis Med Microbiol 22:149–150
    [Google Scholar]
  12. Revankar S.G., Sutton D.A., Rinaldi M.G. ( 2004). Primary central nervous system phaeohyphomycosis: a review of 101 cases. Clin Infect Dis 38:206–216 [CrossRef]
    [Google Scholar]
  13. Werlinger K.D., Yen M.A. ( 2005). Eumycotic mycetoma caused by Cladophialophora bantiana in a patient with systemic lupus erythematosus. J Am Acad Dermatol 52:114–117 [CrossRef]
    [Google Scholar]
  14. Zhang Z., Schwartz S., Wagner L., Miller W. ( 2000). A greedy algorithm for aligning DNA sequences. J Comput Biol 7:203–214 [CrossRef]
    [Google Scholar]
/content/journal/jmmcr/10.1099/jmmcr.0.002659
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.002659
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error