1887

Abstract

Introduction:

A 41‐year‐old man with a history of alcoholic cirrhosis presented to Patan Hospital in Kathmandu, Nepal, with a severe headache.

Case presentation:

Clinical examination found an isolated sixth nerve palsy of the left side with normal blood parameters and a normal brain scan. An initial cerebrospinal fluid analysis found lymphocytosis, with a significantly elevated protein level and reduced glucose. Tubercular meningitis was considered; however, the patient did not improve and a re‐examination of the cerebrospinal fluid confirmed cryptococcal meningitis.

Conclusion:

After diagnosis the patient was treated with amphotericin B. Despite all efforts the patient died 5 days later.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.001982
2014-09-01
2020-08-11
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/1/3/jmmcr001982.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.001982&mimeType=html&fmt=ahah

References

  1. Bicanic T., Harrison T.S.. ( 2005;). Cryptococcal meningitis. Br Med Bull2005:99–118[CrossRef]
    [Google Scholar]
  2. CDC( 2013;). Cryptococcus neoformans cryptococcosis. Cryptococcosis statisticshttp://www.cdc.gov/fungal/cryptococcosis-neoformans/statistics.html
    [Google Scholar]
  3. Coagliati M.. ( 2013;). Global molecular epidemiology of Crypotococcus neoformans and Cryptococcus gattii: an atlas of the molecular types. Scientifica2013:23
    [Google Scholar]
  4. Graybill J.R., Sobel J., Saag M., Van Der Horst C., Powderly W., Cloud G., Riser L., Hamill R., Dismukes W.. ( 2000;). Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups. Clin Infect Dis30:47–54[CrossRef]
    [Google Scholar]
  5. Hsu C.C., Leevy C.M.. ( 1971;). Inhibition of PHA‐stimulated lymphocyte transformation by plasma from patients with advanced alcoholic cirrhosis. Clin Exp Immunol8:749–760
    [Google Scholar]
  6. Mabee C.L., Mabee S.W., Kirkpatrick R.B., Koletar S.L.. ( 1995;). Cirrhosis: a risk factor for cryptococcal peritonitis. Am J Gastroenterol90:2042–2045
    [Google Scholar]
  7. Malik R., Mookerjee R.P., Jalan R.. ( 2009;). Infection and inflammation in liver failure: two sides of the same coin. J Hepatol51:426–429[CrossRef]
    [Google Scholar]
  8. Nouri‐Aria K.T., Alexander G., Portman B.C., Hegarty J.E., Eddleston A., Williams R.. ( 1986;). T and B cell function in alcoholic liver disease. J Hepatol2:195–207[CrossRef]
    [Google Scholar]
  9. Perfect J.R., Casadevall A.. ( 2002;). Cryptococcosis. Infect Dis Clin North Am2002:837–874[CrossRef]
    [Google Scholar]
  10. Saag M.S., Powderly W., Cloud G.A., Robinson P., Grisco M.H., Sharkey P.K.. ( 1992;). Comparision of amphotericin B with fluconazole in the treatment of acute AIDS‐associated cryptococcal meningitis. The NIAID Mycoses Study Group and the AIDS Clinical Trails Group. N Engl J Med1992:83–89[CrossRef]
    [Google Scholar]
  11. Tritto G., Bechlis Z., Stadbauer V., Davies N., Frances R., Al E.. ( 2011;). Evidence of neutrophil functional defect despite inflammation in stable cirrhosis. J Hepatol51:574–581[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.001982
Loading

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error