Coinfection by avirulent and as a cause of atypical abortion in a thoroughbred mare Open Access

Abstract

Introduction:

The majority of abortions in mares are associated with placental infections caused by opportunistic bacteria. is widespread in the environment of stud farms and is found on the mucosal surfaces of horses. Both can occasionally cause placental infection and abortion in mares. To the best of our knowledge, however, there have been no reports of and coinfection in mares experiencing placentitis and abortion. The present report describes an uncommon case of abortion caused by and coinfection in a thoroughbred mare in Brazil, in which the virulence profile of was investigated.

Case Presentation:

A 6‐year‐old thoroughbred mare, in her first pregnancy, showed increased uteroplacental junction and suspected placentitis on transabdominal ultrasound. The mare aborted a 10‐month‐old female fetus. A field necropsy was performed and hydrallantois was diagnosed.

Conclusion:

Although we isolated an avirulent strain of , coinfection of and in the placenta and uterus probably potentiated the pathogenic effect of these micro‐organisms, resulting in abortion.

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2014-09-01
2024-03-29
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References

  1. Bell K.S., Philp J.C., Aw D.W.J., Christofi N. ( 1998). The genus Rhodococcus . J Appl Microbiol 85:195–210 [CrossRef]
    [Google Scholar]
  2. Blanchard T.L., Varner D.D., Buonanno A.M., Palmer J.E., Hansen T.O., Divers T.J. ( 1987). Hydrallantois in two mares. Eq Vet Sci 7:222–225 [CrossRef]
    [Google Scholar]
  3. Foster R.A. ( 2009). Sistema Reprodutivo da Fêmea. In Bases da Patologia em Veterinária pp. 1263–1315 Edited by McGavin M.D., Zachary J.F. Rio de Janeiro: Elsevier;
    [Google Scholar]
  4. Giles R.C., Donahue J.M., Hong C.B., Tuttle P.A., Petrites‐Murphy M.B., Poonacha K.B., Roberts A.W., Tramontin R.R., Smith B., Swerczek T.W. ( 1993). Causes of abortion, stillbirth and perinatal death in horses – 3,527 cases. J Am Vet Med Ass 203:1170–1175
    [Google Scholar]
  5. Hines T.H. ( 2007). Rhodococcus equi. In Equine Infectious Diseases pp. 281–295 Edited by D.C. Sellon, M.T. Long. Missouri: Elsevier; [CrossRef]
    [Google Scholar]
  6. Hong C.B., Donahue J.M., Giles R.C. Jr, Petrites‐Murphy M.B., Poonacha K.B., Roberts A.W., Smith B.J., Tramontin R.R., Tuttle P.A., Swerczek T.W. ( 1993). Equine abortion and stillbirth in central Kentucky during 1988 and 1989 foaling seasons. J Vet Diagn Investig 5:560–566 [CrossRef]
    [Google Scholar]
  7. Kanaly S.T., Hines S.A., Palmer S.A. ( 1993). Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T‐lymphocyte‐deficient transgenic mice. Infect Immun 61:4929–4932
    [Google Scholar]
  8. Koterba A.M., Haibei G.K., Grimmet J.B. ( 1983). Respiratory distress in a premature foal secondary to hydrops allantois and placentitis. Comp Cont Educ Pract 5:121–125
    [Google Scholar]
  9. Krewer C.C., Spricigo D.A., Botton S.A., Costa M.M., Schrank I., Vargas A.C. ( 2008). Molecular characterization of Rhodococcus equi isolates of horse breeding farms from an endemic region in south of Brazil by multiplex PCR. B Journal Microbiol 39:188–193 [CrossRef]
    [Google Scholar]
  10. Leon A., Richard E., Fortier C., Laugier C., Fortier G., Pronost S. ( 2012). Molecular detection of Coxiella burnetii and Neospora caninum in equine aborted foetuses and neonates. Prev Vet Med 104:179–183 [CrossRef]
    [Google Scholar]
  11. Macpherson M.L. ( 2005). Treatment strategies for mares with placentitis. Theriogenology 64:528–534 [CrossRef]
    [Google Scholar]
  12. Makrai L., Kira K., Kono A., Sasaki Y., Kakuda T., Tsubaki S., Fodor L., Varga J., Takai S. ( 2006). Plasmid profiles of virulent Rhodococcus equi isolates from soil environment on horse‐breeding farms in Hungary. Acta Vet Hung 54:11–18 [CrossRef]
    [Google Scholar]
  13. Marenzoni M.L., Lepri E., Proietti P.C., Bietta A., Coletti M., Timoney P.J., Passamonti F. ( 2012). Causes of equine abortion, stillbirth and neonatal death in central Italy. Vet Rec 170:262a [CrossRef]
    [Google Scholar]
  14. Nakamura Y., Nishi H., Katayama Y., Niwa H., Matsumura T., Anzai T., Ohtsu Y., Tsukano K., Shimizu N., Takai S. ( 2007). Abortion in a thoroughbred mare associated with an infection with avirulent Rhodococcus equi . Vet Rec 161:342–346 [CrossRef]
    [Google Scholar]
  15. Patterson‐Kane J.C., Donahue J.M., Harrison L.R. ( 2002). Placentitis, fetal pneumonia, and abortion due to Rhodococcus equi infection in a thoroughbred. J Vet Diagn Investig 14:157–159 [CrossRef]
    [Google Scholar]
  16. Pereira C.M., Adrien M.L., Ladeira S.R.L., Soares M.P., Assis‐Brasil N.D., Schild A.L. ( 2012). Abortos em equinos na região Sul do Rio Grande do Sul: estudo de 72 casos. Pesq Vet Bras 32:22–26 [CrossRef]
    [Google Scholar]
  17. Podschun R., Ullmann U. ( 1998). Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11:589–603
    [Google Scholar]
  18. Prescott J.F. ( 1991). Rhodococcus equi: an animal and human pathogen. Clin Microbiol Rev 29:2696–2700
    [Google Scholar]
  19. Quinn P.J., Markey B.K., Leonard F.C., Fitzpatrick E.S., Fanning S., Hartigan P.J. ( 2011). Veterinary Microbiology and Microbial Disease, 2nd edn. UK: Wiley‐Blackwell;
    [Google Scholar]
  20. Ribeiro M.G., Seki I., Yasuoka K., Kakuda T., Sasaki Y., Tsubaki S., Takai S. ( 2005). Molecular epidemiology of virulent Rhodococcus equi from foals in Brazil: virulence plasmids of 85‐kb type I, 87‐kb type I, and a new variant, 87‐kb type III. Comp Immunol Microb 28:53–61 [CrossRef]
    [Google Scholar]
  21. Rüsse I., Grunert E. ( 1993). Die wachsende Frucht. In Tiergeburt shilfe pp. 41–55 Edited by Richter J., Götze R. Berlin and Hamburg: Paul Parey;
    [Google Scholar]
  22. Shanahan L.M., Slovis N.M. ( 2011). Leptospira interrogans associated with hydrallantois in 2 pluriparous thoroughbred mares. J Vet Intern Med 25:158–161 [CrossRef]
    [Google Scholar]
  23. Stich K.L., Blanchard T.L. ( 2003). Hydrallantois in mares. Comp Cont Educ Pract 1:71–75
    [Google Scholar]
  24. Szeredi L., Jánosi S., Tenk M. ( 2008). Klebsiella oxytoca as a cause of equine abortion. Acta Vet Hung 56:215–220 [CrossRef]
    [Google Scholar]
  25. Takai S. ( 1997). Epidemiology of Rhodococcus equi infections: a review. Vet Microbiol 56:167–176 [CrossRef]
    [Google Scholar]
  26. Takai S., Tharavichitkul P., Takarn P., Khantawa B., Tamura M., Tsukamoto A., Takayama S., Yamatoda N., Kimura A. other authors( 2003). Molecular epidemiology of Rhodococcus equi of intermediate virulence isolated from patients with and without acquired immune deficiency syndrome in Ching Mai, Thailand. J Infect Dis 188:1717–1723 [CrossRef]
    [Google Scholar]
  27. Van Der Kolk H., Kraus H., Vink‐Nooteboom M. ( 1999). Rhodococcus equi pneumonia in foal. Equine Pract 21:6–9
    [Google Scholar]
  28. Vandeplassche M., Bouters R., Spincemaille J., Bonte P. ( 1976). Dropsy of the fetal sacs in mares: induced and spontaneous abortion. Vet Rec 99:67–69 [CrossRef]
    [Google Scholar]
  29. Waelchli R.O., Ehrensperger F. ( 1988). Two related cases of cerebellar abnormality in equine fetuses associated with hydrops of fetal membranes. Vet Rec 123:513–514 [CrossRef]
    [Google Scholar]
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