1887

Abstract

Introduction:

is the most common opportunistic infection in human immunodeficiency virus (HIV)‐infected patients. However, the infection is increasing in other immunosuppressive‐associated conditions, such as haematological malignancies, organ transplantation, connective tissues diseases, primary immunodeficiency and long‐term corticosteroid therapy. Here, we report a HIV‐negative subject.

Case presentation:

Here, we report a human immunodeficiency virus (HIV)‐negative subject with chronic obstructive pulmonary disease (COPD), and mild hypogammaglobulinaemia, low levels of total CD19 B‐cells, and a transitory decrease in IgG and IgG subclasses who evolved to recurrent pneumonia (PCP). In addition, the patient was co‐infected with spp., and developed oral and oesophageal candidiasis. He was treated with sulfamethoxazole/trimethoprim/pentamidine and improved significantly. These results suggest that, in HIV‐negative subjects, clinicians should be aware of the possible association between mild immunosuppressive illness and COPD in inducing PCP, even with normal levels of T‐cell subsets.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.001578
2014-06-01
2019-12-15
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/1/2/jmmcr001578.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.001578&mimeType=html&fmt=ahah

References

  1. Calderón E.J., de Armas Y., Panizo M.M., Wissmann G.. ( 2013;). Pneumocystis jirovecii pneumonia in Latin America. A public health problem?. Expert Rev Anti Infect Ther11:565–570[CrossRef]
    [Google Scholar]
  2. Driessen G.J., Dalm V.A., van Hagen P.M., Grashoff H.A., Hartwig N.G., van Rossum A.M., Warris A., de Vries E., Barendregt B.H.. other authors( 2013;). Common variable immunodeficiency and idiopathic primary hypogammaglobulinemia: two different conditions within the same disease spectrum. Haematologica98:1617–1623[CrossRef]
    [Google Scholar]
  3. Jacobs J.L., Libby D.M., Winters R.A., Gelmont D.M., Fried E.D., Hartman B.J., Laurence J.. ( 1991;). A cluster of Pneumocystis carinii pneumonia in adults without predisposing illnesses. N Engl J Med24:246–250[CrossRef]
    [Google Scholar]
  4. Kelly M.N., Shellito J.E.. ( 2010;). Current understanding of Pneumocystis immunology. Future Microbiol5:43–65[CrossRef]
    [Google Scholar]
  5. Kling H.M., Shipley T.W., Patil S.P., Kristoff J., Bryan M., Montelaro R.C., Morris A., Norris K.A.. ( 2010;). Relationship of Pneumocystis jiroveci humoral immunity to prevention of colonization and chronic obstructive pulmonary disease in a primate model of HIV infection. Infect Immun78:4320–4330[CrossRef]
    [Google Scholar]
  6. Lund F.E., Schuer K., Hollifield M., Randall T.D., Garvy B.A.. ( 2003;). Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P. . carinii‐specific antibody. J Immunol1:1423–1430
    [Google Scholar]
  7. Nevez G., Raccurt C., Jounieaux V., Dei‐Cas E., Mazars E.. ( 1999;). Pneumocystosis versus pulmonary Pneumocystis carinii colonization in HIV‐negative and HIV‐positive patients. AIDS11:535–536[CrossRef]
    [Google Scholar]
  8. Norris K.A., Morris A.. ( 2011;). Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease. Immunol Res50:175–180[CrossRef]
    [Google Scholar]
  9. Nüesch R., Bellini C., Zimmerli W.. ( 1999;). Pneumocystis carinii pneumonia in human immunodeficiency virus (HIV)‐positive and HIV‐negative immunocompromised patients. Clin Infect Dis29:1519–1523[CrossRef]
    [Google Scholar]
  10. Overgaard U.M., Helweg‐Larsen J.. ( 2007;). Pneumocystis jiroveci pneumonia (PCP) in HIV‐1‐negative patients: a retrospective study 2002–2004. Scand J Infect Dis39:589–595[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.001578
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.001578
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error