Recurrent pneumocystosis pneumonia/chronic obstructive pulmonary disease and mild immunodeficiency in a human immunodeficiency virus‐negative subject

Luís Euribel Prestes‐Carneiro; Niuton Gonçalves Santos Junior; Martina Rodrigues Oliveira; Lorena Sagrilo Auer; Alberto José Silva Duarte; Alexandre Almeida; Dewton Moraes Vasconcelos

doi:10.1099/jmmcr.0.001578

Volume 1, Issue 2

Research Article

Open Access

Recurrent pneumocystosis pneumonia/chronic obstructive pulmonary disease and mild immunodeficiency in a human immunodeficiency virus‐negative subject

Luís Euribel Prestes‐Carneiro^1,2, Niuton Gonçalves Santos Junior¹, Martina Rodrigues Oliveira¹, Lorena Sagrilo Auer¹, Alberto José Silva Duarte³, Alexandre Almeida³ and Dewton Moraes Vasconcelos³
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Affiliations: ¹ Ipiranga Hospital, Department of Infectious Diseases and Internal Medicine, Sao Paulo, SP, Brazil ² Department of Immunology, Oeste Paulista University, Presidente Prudente, SP, Brazil ³ Laboratory of Medical Investigation Unit 56, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, SP, Brazil
Correspondence Luiz Euribel Prestes‐Carneiro [email protected]
Published: 01 June 2014 https://doi.org/10.1099/jmmcr.0.001578

Abstract

Introduction:

Pneumocystis jiroveci is the most common opportunistic infection in human immunodeficiency virus (HIV)‐infected patients. However, the infection is increasing in other immunosuppressive‐associated conditions, such as haematological malignancies, organ transplantation, connective tissues diseases, primary immunodeficiency and long‐term corticosteroid therapy. Here, we report a HIV‐negative subject.

Case presentation:

Here, we report a human immunodeficiency virus (HIV)‐negative subject with chronic obstructive pulmonary disease (COPD), and mild hypogammaglobulinaemia, low levels of total CD19+ B‐cells, and a transitory decrease in IgG and IgG subclasses who evolved to recurrent Pneumocystis pneumonia (PCP). In addition, the patient was co‐infected with Candida spp., and developed oral and oesophageal candidiasis. He was treated with sulfamethoxazole/trimethoprim/pentamidine and improved significantly. Conclusion: These results suggest that, in HIV‐negative subjects, clinicians should be aware of the possible association between mild immunosuppressive illness and COPD in inducing PCP, even with normal levels of T‐cell subsets.

Received: 20/01/2014
Accepted: 29/04/2014
Published Online: 01/06/2014

Keyword(s): CD19+ B‐cells , chronic obstructive pulmonary disease , Pneumocystis pneumonia and sulfamethoxazole‐trimethoprim

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/).

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Recurrent pneumocystosis pneumonia/chronic obstructive pulmonary disease and mild immunodeficiency in a human immunodeficiency virus‐negative subject

JMM Case Rep 1, e001578 (2014); https://doi.org/10.1099/jmmcr.0.001578

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Volume 1, Issue 2

Research Article

Open Access

Recurrent pneumocystosis pneumonia/chronic obstructive pulmonary disease and mild immunodeficiency in a human immunodeficiency virus‐negative subject

Abstract

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