1887

JMM Case Reports

Volume 1, Issue 2

Recurrent pneumonia/chronic obstructive pulmonary disease and mild immunodeficiency in a human immunodeficiency virus‐negative subject Open Access

Abstract

Introduction:

is the most common opportunistic infection in human immunodeficiency virus (HIV)‐infected patients. However, the infection is increasing in other immunosuppressive‐associated conditions, such as haematological malignancies, organ transplantation, connective tissues diseases, primary immunodeficiency and long‐term corticosteroid therapy. Here, we report a HIV‐negative subject.

Case presentation:

Here, we report a human immunodeficiency virus (HIV)‐negative subject with chronic obstructive pulmonary disease (COPD), and mild hypogammaglobulinaemia, low levels of total CD19 B‐cells, and a transitory decrease in IgG and IgG subclasses who evolved to recurrent pneumonia (PCP). In addition, the patient was co‐infected with spp., and developed oral and oesophageal candidiasis. He was treated with sulfamethoxazole/trimethoprim/pentamidine and improved significantly. These results suggest that, in HIV‐negative subjects, clinicians should be aware of the possible association between mild immunosuppressive illness and COPD in inducing PCP, even with normal levels of T‐cell subsets.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): CD19+ B‐cells , chronic obstructive pulmonary disease , Pneumocystis pneumonia and sulfamethoxazole‐trimethoprim
© 2014 The Authors
  • This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/).
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/content/journal/jmmcr/10.1099/jmmcr.0.001578
2014-06-01
2023-06-07
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Recurrent pneumocystosis pneumonia/chronic obstructive pulmonary disease and mild immunodeficiency in a human immunodeficiency virus‐negative subject
JMM Case Rep 1, e001578 (2014); https://doi.org/10.1099/jmmcr.0.001578
/content/journal/jmmcr/10.1099/jmmcr.0.001578
/content/journal/jmmcr/10.1099/jmmcr.0.001578
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