RT Journal Article SR Electronic(1) A1 Longin, Pavel A1 Valeckova, Marie A1 Bilek, Ales A1 Melichar, AntoninYR 2014 T1 Local application of fidaxomicin in a patient with subtotal colectomy following recurring Clostridium difficile infection JF JMM Case Reports, VO 1 IS 1 OP SP e001172 DO https://doi.org/10.1099/jmmcr.0.001172 PB Microbiology Society, SN 2053-3721, AB Introduction: Clostridium difficile is the leading cause of antibiotic‐associated diarrhoea and is a major burden to healthcare services worldwide. Fidaxomicin is a first‐in‐class macrocyclic antibiotic that was approved for the treatment of C. difficile infection (CDI) in 2011, demonstrating a narrow spectrum of activity and comparable efficacy to vancomycin in clinical trials. Case presentation: We present the case of a patient with recurrent CDI who was non‐responsive to standard treatment with metronidazole and vancomycin. The patient subsequently developed toxic megacolon, which had to be treated surgically by subtotal colectomy. Fidaxomicin at 200 mg twice daily was delivered in small‐volume enemas directly to the oral part of the sigmoid colon to preserve the remaining rectosigmoid colon and improve the chances of restoring gastrointestinal tract continuity. After 11 days of local fidaxomicin therapy, diagnostic tests revealed that the patient was C. difficile negative and no recurrence of CDI was observed. Restoration of the gastrointestinal tract was successfully completed 5 months after hospital discharge. Conclusion: This report describes a novel concept of local fidaxomicin delivery to the rectosigmoid colon, with an improved clinical outcome compared with metronidazole and vancomycin treatment. The study suggests that topical application of fidaxomicin may be beneficial in some CDI patients following surgical treatment for toxic megacolon. , UL https://www.microbiologyresearch.org/content/journal/jmmcr/10.1099/jmmcr.0.001172