%0 Journal Article %A Taga, Shu %A Yagi, Tetsuya %A Uchiya, Kei‐ichi %A Shibata, Yuichi %A Hamaura, Hiromitsu %A Nakagawa, Taku %A Hayashi, Yuta %A Nikai, Toshiaki %A Ogawa, Kenji %T Recurrence of pulmonary Mycobacterium avium complex disease due to endogenous reactivation %D 2014 %J JMM Case Reports, %V 1 %N 2 %@ 2053-3721 %C e000935 %R https://doi.org/10.1099/jmmcr.0.000935 %K residential bathroom %K pulmonary Mycobacterium avium complex disease %K VNTR analysis %K reinfection %K endogenous reactivation %I Microbiology Society, %X Introduction: An official American Thoracic Society and Infectious Disease Society of America statement has shown that patients with pulmonary Mycobacterium avium complex (MAC) disease who complete 10–12 months of negative cultures on therapy but then have either single or multiple positive MAC cultures are more likely to have reinfection with a new MAC strain. Case presentation: A 63‐year‐old woman was diagnosed with pulmonary disease caused by clarithromycin (CAM)‐susceptible MAC. Before initiating chemotherapy using a four‐drug regimen containing CAM, an investigation of the patient’s residential bathroom was conducted and one of the M. avium isolates recovered from the bathtub inlet was found to be genetically identical to sputum‐derived isolates by variable number tandem repeats analysis using M. avium tandem repeat loci (MATR‐VNTR). A second investigation of the bathroom during chemotherapy showed no M. avium isolates, and five consecutive sputum cultures were negative for 12 months until chemotherapy was discontinued. A recurrence occurred 3 months after the end of chemotherapy (at age 65 years). A third investigation of the bathroom was performed and MATR‐VNTR analysis revealed that the VNTR profile of the M. avium isolates recovered from the sputum at recurrence was identical to that of the isolates recovered from the sputum at initial diagnosis and the bathroom at the first investigation. Conclusion: The recurrence occurred due to endogenous reactivation of the initial M. avium isolate despite drug treatment for 12 months after sputum culture conversion. Further genetic analyses of MAC isolates recovered from patients and environments should be encouraged. %U https://www.microbiologyresearch.org/content/journal/jmmcr/10.1099/jmmcr.0.000935