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Abstract

Introduction:

We present a rare case of hypocomplementaemic urticarial vasculitis in a 1‐year‐old girl with a coxsackievirus type A9 (CA9) infection.

Case presentation:

At first, we thought that the patient had Kawasaki disease, but a skin biopsy showed overriding evidence of urticarial vasculitis and serum complement levels were severely reduced. Treatment with prednisolone was effective. We isolated and confirmed CA9 from all samples (nasal fluid, serum and stool). We also analysed CA9 genetically.

Conclusion:

CA9 may induce systemic small‐vessel vasculitis resulting in transient decreases in complements.

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2014-03-01
2020-01-27
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References

  1. Aydogan K., Karadogan S.K., Adim S.B., Tunali S.. ( 2006;). Hypocomplementemic urticarial vasculitis: a rare presentation of systemic lupus erythematosus. Int J Dermatol45:1057–1061[CrossRef]
    [Google Scholar]
  2. Balsam L., Karim M., Miller F., Rubinstein S.. ( 2008;). Crescentic glomerulonephritis associated with hypocomplementemic urticarial vasculitis syndrome. Am J Kidney Dis52:1168–1173[CrossRef]
    [Google Scholar]
  3. Berg R.E., Kantor G.R., Bergfeld W.F.. ( 1988;). Urticarial vasculitis. Int J Dermatol27:468–472[CrossRef]
    [Google Scholar]
  4. Bligard C.A., Millikan L.E.. ( 1986;). Acute exanthems in children. Clues to differential diagnosis of viral disease. Postgraduate Medicine79:150–154159–167
    [Google Scholar]
  5. Cherry J.D., Demmler G.J., Kaplan S.L.. ( 2004;). Enteroviruses and paraechoviruses, Textbook of pediatric infectious Diseases . Philadelphia: Saunders. 5th edn, 1984–2041
  6. Jones R.R., Eady R.A.. ( 1984;). Endothelial cell pathology as a marker for urticarial vasculitis: a light microscopic study. Br J Dermatol110:139–149[CrossRef]
    [Google Scholar]
  7. Kawana S.. ( 1996;). The membrane attack complex of complement alters the membrane integrity of cultured endothelial cells: a possible pathophysiology for immune complex vasculitis. Acta Derm Venereol76:13–16
    [Google Scholar]
  8. Kimura M.. ( 1980;). A simple method for estimating evolutionary rates of base substitution through comparative studies of nucleotide sequences. J Mol Evol16:111–120[CrossRef]
    [Google Scholar]
  9. Lin L.Y., Yang T.H., Lin Y.J., Kuo H.C.. ( 2012;). Comparison of the laboratory data between Kawasaki disease and enterovirus after intravenous immunoglobulin treatment. Pediatr Cardiol33:1269–1274[CrossRef]
    [Google Scholar]
  10. Lotti T., Ghersetich I., Comacchi C., Jorizzo J.L.. ( 1998;). Cutaneous small‐vessel vasculitis. J Am Acad Dermatol39:667–687[CrossRef]
    [Google Scholar]
  11. McDuffie F.C., Sams W.M. Jr, Maldonado J.E., Andreini P.H., Conn D.L., Samayoa E.A.. ( 1973;). Hypocomplementemia with cutaneous vasculitis and arthritis. Possible immune complex syndrome. Mayo Clin Proc48:340–348
    [Google Scholar]
  12. Oberste M.S., Maher K., Flemister M.R., Marchetti G., Kilpatrick D.R., Pallansch M.A.. ( 2000;). Comparison of classic and molecular approaches for the identification of ‘untypeable’ enteroviruses. J Clin Microbiol38:1170–1174
    [Google Scholar]
  13. Saitou N., Nei M.. ( 1987;). The neighbor‐joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol4:406–425
    [Google Scholar]
  14. Schwartz H.R., McDuffie F.C., Black L.F., Schroeter A.L., Conn D.L.. ( 1982;). Hypocomplementemic urticarial vasculitis: association with chronic obstructive pulmonary disease. Mayo Clin Proc57:231–238
    [Google Scholar]
  15. Venzor J., Lee W.L., Huston D.P.. ( 2002;). Urticarial vasculitis. Clin Rev Allergy Immunol23:201–216[CrossRef]
    [Google Scholar]
  16. Wisnieski J.J.. ( 2000;). Urticarial vasculitis. Curr Opin Rheumatol12:24–31[CrossRef]
    [Google Scholar]
  17. Wisnieski J.J., Baer A.N., Christensen J., Cupps T.R., Flagg D.N., Jones J.V., Katzenstein P.L., McFadden. other authors( 1995;). Hypocomplementemic urticarial vasculitis syndrome. Clinical and serologic findings in 18 patients. Medicine74:24–41[CrossRef]
    [Google Scholar]
  18. Wisnieski J.J., Naff G.B.. ( 1989;). Serum IgG antibodies to C1q in hypocomplementemic urticarial vasculitis syndrome. Arthritis Rheum32:1119–1127[CrossRef]
    [Google Scholar]
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