1887

Abstract

Introduction:

is an emerging pathogen. Whilst association with cystic fibrosis (CF) has been described previously, this is the first report to our knowledge of multidrug‐resistant incidence in an Irish CF patient population.

Case presentation:

Using a case series of four adult CF patients with varying baselines of health, one of whom was asymptomatic, this report attempts correlation of colonization, by one common strain, with incidence of acute exacerbation of symptoms. As definitive guidelines for antimicrobial sensitivity/resistance do not exist for , we completed a systematic review of available literature to collate evidence of antimicrobial efficacy against Comparison with the isolates in this study indicated sensitivity to piperacillin/tazobactam and minocycline but resistance to antimicrobials in the macrolide, other β‐lactam and fluoroquinolone groups.

Conclusion:

To our knowledge, this is the first report of multiple CF patients sharing a strain of . Furthermore, may be under‐identified in CF patients and should be considered when evaluating exacerbation of CF symptoms.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.000075
2014-03-01
2019-10-15
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/1/1/jmmcr000075.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.000075&mimeType=html&fmt=ahah

References

  1. Farrell P.M. . ( 2008; ). The prevalence of cystic fibrosis in the European Union. . J Cyst Fibros 7:, 450–453.[CrossRef]
    [Google Scholar]
  2. Fry N.K. , Duncan J. , Malnick H. , Warner M. , Smith A.J. , Jackson M.S. , Ayoub A. . ( 2005; ). Bordetella petrii clinical isolate. . Emerg Infect Dis 11:, 1131–1133.[CrossRef]
    [Google Scholar]
  3. Fry N.K. , Duncan J. , Edwards M T. , Tilley R E. , Chitnavis D. , Harman R. , Hammerton H. , Dainton L. . ( 2007a; ). A UK clinical isolate of Bordetella hinzii from a patient with myelodysplastic syndrome. . J Med Microbiol 56:, 1700–1703.[CrossRef]
    [Google Scholar]
  4. Fry N.K. , Duncan J. , Malnick H. , Cockcroft P M. . ( 2007b; ). The first UK isolate of ‘Bordetella ansorpii’ from an immunocompromised patient. . J Med Microbiol 56:, 993–995.[CrossRef]
    [Google Scholar]
  5. Gerlach G. , von Wintzingerode F. , Middendorf B. , Gross R. . ( 2001; ). Evolutionary trends in the genus Bordetella . . Microbes Infect 3:, 61–72.[CrossRef]
    [Google Scholar]
  6. Gross R. , Guzman C.A. , Sebaihia M. , dos Santos V.A. , Pieper D.H. , Koebnik R. , Lechner M. , Bartels D. , Buhrmester J. . other authors ( 2008; ). The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae. . BMC Genomics 9:, 449.[CrossRef]
    [Google Scholar]
  7. Gross R. , Keidel K. , Schmitt K. . ( 2010; ). Resemblance and divergence: the “new” members of the genus Bordetella . . Med Microbiol Immunol 199:, 155–163.[CrossRef]
    [Google Scholar]
  8. Henry B. , Aussage P. , Grosskopf C. , Goehrs J.M. . ( 2003; ). Development of the Cystic Fibrosis Questionnaire (CFQ) for assessing quality of life in pediatric and adult patients. . Qual Life Res 12:, 63–76.[CrossRef]
    [Google Scholar]
  9. Ko K.S. , Peck K.R. , Oh W.S. , Lee N.Y. , Lee J.H. , Song J.H. . ( 2005; ). New species of Bordetella, Bordetella ansorpii sp. nov., isolated from the purulent exudate of an epidermal cyst. . J Clin Microbiol 43:, 2516–2519.[CrossRef]
    [Google Scholar]
  10. Le Coustumier A. , Njamkepo E. , Cattoir V. , Guillot S. , Guiso N. . ( 2011; ). Bordetella petrii infection with long‐lasting persistence in human. . Emerg Infect Dis 17:, 612–618.[CrossRef]
    [Google Scholar]
  11. Livovsky D.M. , Leibowitz D. , Hidalgo‐Grass C. , Temper V. , Salameh S. , Korem M. . ( 2012; ). Bordetella holmesii meningitis in an asplenic patient with systemic lupus erythematosus. . J Med Microbiol 61:, 1165–1167.[CrossRef]
    [Google Scholar]
  12. Mattoo S. , Cherry J.D. . ( 2005; ). Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. . Clin Microbiol Rev 18:, 326–382.[CrossRef]
    [Google Scholar]
  13. Moissenet D. , Leverger G. , Merens A. , Bonacorsi S. , Guiso N. , Vu‐Thien H. . ( 2011; ). Septic arthritis caused by Bordetella holmesii in an adolescent with chronic haemolytic anaemia. . J Med Microbiol 60:, 1705–1707.[CrossRef]
    [Google Scholar]
  14. Spilker T. , Liwienski A.A. , Lipuma J.J. . ( 2008; ). Identification of Bordetella spp. in respiratory specimens from individuals with cystic fibrosis. . Clin Microbiol Infect 14:, 504–506.[CrossRef]
    [Google Scholar]
  15. Stark D. , Riley L.A. , Harkness J. , Marriott D. . ( 2007; ). Bordetella petrii from a clinical sample in Australia: isolation and molecular identification. . J Med Microbiol 56:, 435–437.[CrossRef]
    [Google Scholar]
  16. von Wintzingerode F. , Gerlach G. , Schneider B. , Gross R. . ( 2002; ). Phylogenetic relationships and virulence evolution in the genus Bordetella . . Curr Top Microbiol Immunol 264:, 177–199.
    [Google Scholar]
  17. von Wintzingerode F. , Schattke A. , Siddiqui R.A. , Rosick U. , Gobel U.B. , Gross R. . ( 2001; ). Bordetella petrii sp. nov., isolated from an anaerobic bioreactor, and emended description of the genus Bordetella . . Int J Syst Evol Microbiol 51:, 1257–1265.[CrossRef]
    [Google Scholar]
  18. Zelazny A.M. , Ding L. , Goldberg J.B. , Mijares L.A. , Conlan S. , Conville P.S. , Stock F. , Ballentine S.J. , Olivier K.N. . other authors ( 2013; ). Adaptability and persistence of the emerging pathogen Bordetella petrii . . PLoS One 8:, e65102.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.000075
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.000075
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error