1887

Abstract

Introduction:

is a recently described species that has been reported in two human cases of cutaneous infection. The present case is, to the best of our knowledge, the first with invasive infection of the sinuses by this fungus and the first report of its isolation from India.

Case presentation:

A 44-year-old woman was diagnosed with a pre-septal cellulitis and pansinusitis. She was non-diabetic and did not have any other co-morbidity. The patient underwent emergency endoscopic endonasal debridement for right pansinusitis with right orbital nerve decompression and left-sided functional endoscopic sinus surgery. A right orbital exenteration was performed to prevent further spread of the infection. Debrided material from the orbit grew , the identity of which was confirmed by molecular techniques. The infection spread subcutaneously to the cheek and neck. The patient was treated with intravenous amphotericin B, to which she responded favourably.

Conclusion:

can cause rhinosinusitis and appears to have a propensity for subcutaneous spread. The fungus is present in the environment in India. Treatment with amphotericin B was successful in our case.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.000044
2015-06-01
2020-09-30
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/2/3/jmmcr000044.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.000044&mimeType=html&fmt=ahah

References

  1. Alvarez E, Garcia-Hermoso D, Sutton D.A, Cano J.F, Stchigel A.M, Hoinard D, Fothergill A.W, Rinaldi M.G, Dromer F, Guarro J. 2010; Molecular phylogeny and proposal of two new species of the emerging pathogenic fungus Saksenaea. J Clin Microbiol48:4410–4416[CrossRef]
    [Google Scholar]
  2. Ellis J.J, Ajello L. 1982; An unusual source of Apophysomyceselegans and a method for stimulating sporulation in Saksenaea vasiformis. Mycologia74:144–145[CrossRef]
    [Google Scholar]
  3. Gomes MZR, Lewis R.E, Kontoyiannis D.P. 2011; Mucormycosis caused by unusual mucormycetes, non-Rhizopus, -Mucor, and -Lichtheimia species. Clin Microbiol Rev24:411–445[CrossRef]
    [Google Scholar]
  4. Gonis G, Starr M. 1997; Fatal rhinoorbital mucormycosis caused by Saksenaeavasiformis in an immunocompromised child. Pediatr Infect Dis J16:714–716[CrossRef]
    [Google Scholar]
  5. Hospenthal D.R, Chung K.K, Lairet K, Thompson E.H, Guarro J, Renz E.M, Sutton D.A. 2011; Saksenaea erythrospora infection following combat trauma. J Clin Microbiol49:3707–3709[CrossRef]
    [Google Scholar]
  6. Kaufman L, Padhye A.A, Parker S. 1988; Rhinocerebral zygomycosis caused by Saksenaea vasiformis. J Med Vet Mycol26:237–241[CrossRef]
    [Google Scholar]
  7. Lawhon S.D, Corapi W.V, Hoffmann A.R, Libal M.C, Alvarez E, Guarro J, Wickes B.L, Fu J, Thompson E.H, Sutton D.A. 2012; In utero infection of a calf by Saksenaea erythrospora resulting in neonatal abomasitis and dermatitis. J Vet Diagn Invest24:990–993[CrossRef]
    [Google Scholar]
  8. Möller E.M, Bahnweg G, Sandermann H, Geiger H.H. 1992; A simple and efficient protocol for isolation of high molecular weight DNA from filamentous fungi, fruit bodies, and infected plant tissues. Nucleic Acids Res20:6115–6116[CrossRef]
    [Google Scholar]
  9. Relloso S, Romano V, Landaburu M.F, Herrera F, Smayevsky J, Veciño C, Mujica M.T. 2014; Saksenaea erythrospora infection following a serious sailing accident. J Med Microbiol63:317–321[CrossRef]
    [Google Scholar]
  10. Ribes J.A, Vanover-Sams C.L, Baker D.J. 2000; Zygomycetes in human disease. Clin Microbiol Rev13:236–301[CrossRef]
    [Google Scholar]
  11. Ronquist F, Teslenko M, van der Mark P, Ayres D.L, Darling A, Höhna S, Larget B, Liu L, Suchard M.A, Huelsenbeck J.P. 2012; MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Syst Biol61:539–542[CrossRef]
    [Google Scholar]
  12. Saksena S.B. 1953; A new genus of the Mucorales. Mycologia456:426–436
    [Google Scholar]
  13. Taj-Aldeen S.J, Falamarzi A, AlMuzrkchi A, Guarro J. 2012; Rare pediatric rhino-orbital infection caused by Saksenaea vasiformis. Infection40:703–707[CrossRef]
    [Google Scholar]
  14. Tendolkar U.M, Gogate A.S. 1997; Simplified Grocott's methenamine silver nitrate method for staining fungi. Indian J Med Microbiol15:127–129
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.000044
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.000044
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error