1887

Abstract

Introduction:

The number of fungal infections caused by uncommon fungi has increased in recent years. is a yeast species that is a rare cause of human infections. In previous cases, isolation of has been reported only from blood specimens and only infrequently. This report describes what we believe is the first case of isolation of from a urine specimen of an immunocompromised 5-year-old child who had a history of prolonged hospitalization and exposure to multiple antibacterial agents and who was neutropenic.

Case presentation:

A 5-year-old male child presented in paediatric emergency in a febrile (103 °F), conscious but confused and irritable state. A number of risk factors were present in the child including an immunocompromised state, prolonged prior hospitalization, exposure to multiple antibiotics, indwelling catheters and neutropenia. A urine culture showed pure and significant growth of sp., which was identified as (resistant to amphotericin B) by Vitek 2 Compact (bioMérieux). Subsequent 26S rRNA gene sequencing identified it as .

Conclusion:

Molecular assays have a major role in confirming the identity of uncommon fungal isolates, as correct identification is important for epidemiological purposes. It is imperative that antifungal susceptibility should be performed along with identification of the sp.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.000033
2015-08-01
2021-10-23
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/2/4/jmmcr000033.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.000033&mimeType=html&fmt=ahah

References

  1. Abi-Said D., Anaissie E., Uzun O., Raad I., Pinzcowski H., Vartivarian S. ( 1997). The epidemiology of hematogenous candidiasis caused by different Candida species. Clin Infect Dis 24:1122–1128 [CrossRef]
    [Google Scholar]
  2. Alsina A., Mason M., Uphoff R.A., Riggsby W.S., Becker J.M., Murphy D. ( 1988). Catheter-associated Candida utilis fungemia in a patient with acquired immunodeficiency syndrome: species verification with a molecular probe. J Clin Microbiol 26:621–624
    [Google Scholar]
  3. Arendrup M.C. ( 2010). Epidemiology of invasive candidiasis. Curr Opin Crit Care 16:445–452 [CrossRef]
    [Google Scholar]
  4. Bhally H.S., Jain S., Shields C., Halsey N., Cristofalo E., Merz W.G. ( 2006). Infection in a neonate caused by Pichia fabianii: importance of molecular identification. Med Mycol 44:185–187 [CrossRef]
    [Google Scholar]
  5. Bougnoux M.E., Gueho E., Potocka A.C. ( 1993). Resolutive Candida utilis fungemia in a nonneutropenic patient. J Clin Microbiol 31:1644–1645
    [Google Scholar]
  6. Gabriel F., Noel T., Accoceberry I. ( 2012). Lindnera (Pichia) fabianii blood infection after mesenteric ischemia. Med Mycol 50:310–314 [CrossRef]
    [Google Scholar]
  7. Grenouillet F., Millon L., Chamouine A., Thiriez G., Schulze O., Leroy J. ( 2010). Pichia fabianii fungemia in a neonate. Pediatr Infect Dis J 29:191 [CrossRef]
    [Google Scholar]
  8. Hamal P., Ostransky J., Dendis M., Horváth R., Ruzicka F., Buchta V., Vejsova M., Sauer P., Hejnar P., Raclavsky V. ( 2008). A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment. Med Mycol 46:601–605 [CrossRef]
    [Google Scholar]
  9. Hazen K.C. ( 1995). New and emerging yeast pathogens. Clin Microbiol Rev 8:462–478
    [Google Scholar]
  10. Hazen K.C., Theisz G.W., Howell S.A. ( 1999). Chronic urinary tract infection due to Candida utilis . J Clin Microbiol 37:824–827
    [Google Scholar]
  11. Jain M., Dogra V., Mishra B., Thakur A., Loomba P.S., Bhargava A. ( 2011). Candiduria in catheterized intensive care unit patients: emerging microbiological trends. Indian J Pathol Microbiol 54:552–555 [CrossRef]
    [Google Scholar]
  12. Lukić-Grlić A., Mlinarić-Missoni E., Skarić I., Vazić-Babić V., Svetec I.K. ( 2011). Candida utilis candidaemia in neonatal patients. J Med Microbiol 60:838–841 [CrossRef]
    [Google Scholar]
  13. Shih M.H., Sheu M.M., Chen H.Y., Lin S.R. ( 1999). Fungal keratitis caused by Candida utilis – case report. Kaohsiung J Med Sci 15:171–174
    [Google Scholar]
  14. Valenza G., Valenza R., Brederlau J., Frosch M., Kurzai O. ( 2006). Identification of Candida fabianii as a cause of lethal septicaemia. Mycoses 49:331–334 [CrossRef]
    [Google Scholar]
  15. Wu Y., Wang J., Li W., Jia H., Che J., Lu J., Liu L., Cheng Y. ( 2013). Pichia fabianii blood infection in a premature infant in China: case report. BMC Res Notes 6:77 [CrossRef]
    [Google Scholar]
  16. Yun J.W., Park K.S., Ki C.S., Lee N.Y. ( 2013). Catheter-related bloodstream infection by Lindnera fabianii in a neutropenic patient. J Med Microbiol 62:922–925 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.000033
Loading

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error