1887

Abstract

Introduction:

The number of infections due to uncommon yeast species is gradually increasing worldwide. In cases of high-risk paediatric patients, has been identified as the causal agent in a number of countries. In fact, we have recently reported the first proven occurrence, to the best of our knowledge, of this species as a causal agent of fungaemia in three neonatal patients in a Croatian hospital.

Case presentation:

We report here six new instances of clinically manifested bloodstream and urinary tract infections caused by in five high-risk neonates and one child, during a 5-year period (2008–2012) in the aforementioned Croatian hospital. In addition, we have provided an account of their treatment strategy and the outcome, and the susceptibility profiles of 44 isolates of to amphotericin B, flucytosine, triazoles and echinocandins. Furthermore, we have described a novel molecular method suitable for the rapid and specific diagnosis of this species.

Conclusion:

Our findings demonstrated: (i) the pathogenic activities of species in high-risk children; (ii) that administering fluconazole either prophylactically or therapeutically yielded no results in 50 % of the patients; (iii) that substituting fluconazole by liposomal amphotericin B or caspofungin managed to resolve sepsis in the remaining 50 % of patients; (iv) that, according to the examined sequences, all of the isolates were found to be identical independent of their source or study period; and (v) the existence of a higher proportion of non-susceptible isolates of for echinocandins (especially micafungin) compared with the other tested antifungals.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.000032
2015-06-01
2019-10-16
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/2/3/jmmcr000032.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.000032&mimeType=html&fmt=ahah

References

  1. Bhally H. S. , Jain S. , Shields C. , Halsey N. , Cristofalo E. , Merz W. G. . 2006; Infection in a neonate caused by Pichia fabianii: importance of molecular identification. Med Mycol 44: 185– 187 [CrossRef]
    [Google Scholar]
  2. Brissaud O. , Guichoux J. , Harambat J. , Tandonnet O. , Zaoutis T. . 2012; Invasive fungal disease in PICU: epidemiology and risk factors. Ann Intensive Care 2: 6 [CrossRef]
    [Google Scholar]
  3. Dooley D. P. , Beckius M. L. , McAllister C. K. , Jeffery B. S. . 1990; Prostatitis caused by Hansenula fabianii. J Infect Dis 161: 1040– 1041 [CrossRef]
    [Google Scholar]
  4. Freel K. C. , Sarilar V. , Neuvéglise C. , Devillers H. , Friedrich A. , Schacherer J. . 2014; Genome sequence of the yeast Cyberlindera fabianii (Hansuela fabianii). Genome 2: e00638– e00614
    [Google Scholar]
  5. Gabriel F. , Noel T. , Accoceberry I. . 2012; Lindnera (Pichia) fabianii blood infection after mesenteric ischemia. Med Mycol 50: 310– 314 [CrossRef]
    [Google Scholar]
  6. Grenouillet F. , Millon L. , Chamouine A. , Thiriez G. , Schulze O. , Leroy J. . 2010; Pichia fabianii fungemia in a neonate. Pediatr Infect Dis J 29: 191 [CrossRef]
    [Google Scholar]
  7. Hamal P. , Ostransky J. , Dendis M. , Horváth R. , Ruzicka F. , Buchta V. , Vejsova M. , Sauer P. , Hejnar P. , Raclavsky V. . 2008; A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment. Med Mycol 46: 601– 605 [CrossRef]
    [Google Scholar]
  8. Hope W. W. , Castagnola E. , Groll A. H. , Roilides E. , Akova M. , Arendrup M. C. , Arikan-Akdagli S. , Bassetti M. , Bille J. , other authors . 2012; ESCMID guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp. Clin Microbiol Infect 18: 38– 52 [CrossRef]
    [Google Scholar]
  9. Kaufman D. , Fairchild K. D. . 2004; Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin Microbiol Rev 17: 638– 680 [CrossRef]
    [Google Scholar]
  10. Kocsubé S. , Tóth M. , Vágvölgyi C. , Dóczi I. , Pesti M. , Pócsi I. , Szabó J. , Varga J. . 2007; Occurrence and genetic variability of Candida parapsilosis sensu lato in Hungary. J Med Microbiol 56: 190– 195 [CrossRef]
    [Google Scholar]
  11. Lukić-Grlić A. , Mlinarić-Missoni E. , Škarić I. , Važić-Babić V. , Svetec I. K. . 2011; Candida utilis candidaemia in neonatal patients. J Med Microbiol 60: 838– 841 [CrossRef]
    [Google Scholar]
  12. Robinson J. L. , Davies H. D. , Barton M. , O'Brian K. , Simpson K. , Asztalos E. , Synnes A. , Rubin E. , LeSaux N. , other authors . 2009; Characteristics and outcome of infants with candiduria in neonatal intensive care – a Paediatric Investigators Collaborative network on Infections in Canada (PICNIC) study. BMC Infectious Dis 9: 183 [CrossRef]
    [Google Scholar]
  13. Silvestro D. , Michalak I. . 2011; RaxmIGUI: a graphical front-end for RaxML. Org Divers Evol 12: 335– 337 [CrossRef]
    [Google Scholar]
  14. Trnka P. , Kralik J. , Pevalova L. , Tuharsky J. , Sagat T. , Hudecova N. , Krchova D. , Krcmeryova T. , West D. , other authors . 1998; Candiduria in critically ill children: risk factors and predictors of mortality. Infect Dis Clin Pract 7: 234– 239 [CrossRef]
    [Google Scholar]
  15. Valenza G. , Valenza R. , Brederlau J. , Frosch M. , Kurzai O. . 2006; Identification of Candida fabianii as a cause of lethal septicaemia. Mycoses 49: 331– 334 [CrossRef]
    [Google Scholar]
  16. White T. J. , Bruns T. , Lee S. , Taylor J. . 1990; Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. . In PCR Protocols, a Guide to Methods and Applications, pp. 315– 322. Edited by Innis M. A. , Gelfand D. H. , Sninsky J. J. , White T. J. . San Diego, CA: Academic Press;
    [Google Scholar]
  17. Wu Y. , Wang J. , Li W. , Jia H. , Che J. , Lu J. , Liu L. , Cheng Y. . 2013; Pichia fabianii blood infection in a premature infant in China: case report. BMC Res Notes 6: 77 [CrossRef]
    [Google Scholar]
  18. Wynn J. L. , Tan S. , Gantz M. G. , Das A. , Goldberg R. N. , Adams-Chapman I. , Stoll B. J. , Shankaran S. , Walsh M. C. , other authors . 2012; Outcomes following candiduria in extremely low birth weight infants. Clin Infect Dis 54: 331– 339 [CrossRef]
    [Google Scholar]
  19. Yun J. W. , Park K. S. , Ki Ch-S. , Lee N. Y. . 2013; Catheter-related bloodstream infection by Lindnera fabianii in a neutropenic patient. J Med Microbiol 62: 922– 925 [CrossRef]
    [Google Scholar]
  20. Zaoutis T. E. , Prasad P. A. , Localio R. , Coffin S. E. , Bell L. M. , Walsh T. J. , Gross R. . 2010; Risk factors and predictors for candidaemia in paediatric intensive care unit patients: implications for prevention. Clin Infect Dis 51: e38– e45 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.000032
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.000032
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error