Post‐operative mediastinitis due to multidrug‐resistant Gram‐negative bacteria has rarely been described and is associated with increased mortality.

Case presentation:

We report a case of mediastinitis caused by a multidrug‐resistant OXA‐48‐producing isolate in a patient who underwent coronary artery bypass grafting. Successful treatment consisted of surgical debridement and prolonged administration of imipenem and colistin.


This result shows that a combination of imipenem/colistin could be used to treat serious infections with carbapenemase‐producing .


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