1887

JMM Case Reports

Volume 2, Issue 1

Infection caused by the yeast form of Open Access

Abstract

Introduction:

Paracoccidioidomycosis (PCM) is caused by the dimorphic fungus . Infection occurs mainly through the upper airways of the host by inhalation of spores or propagules of the micro‐organism that settle initially in the lungs. Here, we describe a clinical case report of PCM acquired by a researcher following a scientific laboratory accident; to the best of our knowledge, this is the first report of infection with the yeast form of .

Case presentation:

A 40‐year‐old, white, healthy, male researcher, while undertaking experimental activities in a laboratory environment with fungus infection in guinea pigs, pierced the thumb of the left hand, with a 1 ml syringe containing 50 μl of a suspension of at a concentration of 1×10 c.f.u. ml. Seven days after the accident, the region had local swelling, redness and pain on stimulation. He was started on medical treatment and opted for surgical removal. A biopsy revealed an inflammatory infiltrate, numerous epithelioid granulomas and a discrete quantity of yeast organisms on the dermis, some with multiple budding yeast cells presenting characteristics of viability, with conclusive diagnosis of PCM. After 90 days of itraconazole treatment at 200 mg day, he reported healing with scar formation.

Conclusion:

The yeast form of is able to cause infection. According to our knowledge, this is the first time that this has been reported in the medical literature.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): accident , infection , Paracoccidioides brasiliensis and Paracoccidioidomycosis
© 2015 The Authors
  • This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/).
Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.000016
2015-02-01
2024-04-23
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/2/1/jmmcr000016.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.000016&mimeType=html&fmt=ahah

References

  1. Bagagli E., Theodoto R.C., Bosco S.M.G., McEwen J.G. ( 2008). Paracoccidioides brasiliensis: phylogenetic and ecological aspects. Mycopathologia 165:197–207 [CrossRef]
     [Google Scholar]
  2. Borges‐Walmsley M.I., Chen X., Walmsley A.R. ( 2002). The pathobiology of Paracoccidioides brasiliensis . Trends Microbiol 10:80–87 [CrossRef]
     [Google Scholar]
  3. Camargo Z.P., Franco M.F. ( 2000). Current knowledge on pathogenesis and immunodiagnosis of paracoccidioidomycosis. Rev Iberoam Micol 17:41–48
     [Google Scholar]
  4. Franco M.F., Montenegro M.R.G., Mendes R.P., Marcos A.S., Dillon N.L., Mota N.G.S. ( 1987). Paracoccidioidomycosis: a recently proposed classification of its clinical forms. Rev Soc Bras Med Trop 20:129–132 [CrossRef]
     [Google Scholar]
  5. Giraldo R., Restrepo A., Gutierrez F., Londono Robledo. M., Hernandez F., Sierra H. F. Calle G. ( 1976). Pathogenesis of paracoccidioidomycosis: a model based on the study of 46 patients. Mycopathologia 58:63–70 [CrossRef]
     [Google Scholar]
  6. Lutz A. ( 1908). Uma mycose pseudococcidica localizada na bocca e observada no Brazil. Contribuição ao conhecimento das Hyphoblastomycoses americanas. O Brasil‐Medico. Revista Semanal de Medicina e Cirurgia 22:121–124
     [Google Scholar]
  7. Mendes‐Giannini M.J., Monteiro da Silva J.L., Fátima da Silva J., Donofrio F.C., Miranda E.T., Andreotti P.F., Soares C.P. ( 2008). Interactions of Paracoccidioides brasiliensis with host cells: recent advances. Mycopathologia 165:237–248 [CrossRef]
     [Google Scholar]
  8. Negroni R. ( 1993). Paracoccidioidomycosis (South American blastomycosis, Lutz’s mycosis). Int J Dermatol 32:847–859 [CrossRef]
     [Google Scholar]
  9. Restrepo A. ( 1985). The ecology of Paracoccidioides brasiliensis: a puzzle still unsolved. Sabouraudia 23:323–334 [CrossRef]
     [Google Scholar]
  10. Roldán J.C., Tabares A.M., Gómez B.L., Aristizabal B.E., Cock A.M., Restrepo A. ( 2000). The oral route in the pathogenesis of paracoccidioidomycosis: an experimental study in BALB/c mice infected with P. . brasiliensis conidia. Mycopathologia 151:57–62 [CrossRef]
     [Google Scholar]
  11. San‐Blas G., Niño‐Vega G., Iturriaga T. ( 2002). Paracoccidioides brasiliensis and paracoccidioidomycosis: molecular approaches to morphogenesis, diagnosis, epidemiology, taxonomy and genetics. Med Mycology 4:225–242 [CrossRef]
     [Google Scholar]
  12. Valera E.T., Mori B.M., Engel E.E., Costa I.S., Brandão D.F., Nogueira‐Barbosa M.H., Queiroz R.G., Silveira V.d.S., Scrideli C.A., Tone L.G. ( 2008). Fungal infection by Paracoccidioides brasiliensis mimicking bone tumor. Pediatr Blood Cancer 50:1284–1286 [CrossRef]
     [Google Scholar]
  13. Wanke B., Londero A.T. ( 1994). Epidemiology and paracoccidioidomycosis infection. In Paracoccidioidomycosis109–120 Franco M, Lacaz C S, Restrepo‐Moreno A, Del Negro G. Boca Raton, FL: CRC Press;
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.000016
Loading
Infection caused by the yeast form of Paracoccidioides brasiliensis
JMM Case Rep 2, e000016 (2015); https://doi.org/10.1099/jmmcr.0.000016
/content/journal/jmmcr/10.1099/jmmcr.0.000016
/content/journal/jmmcr/10.1099/jmmcr.0.000016
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error