1887

Abstract

Introduction:

Paracoccidioidomycosis (PCM) is caused by the dimorphic fungus . Infection occurs mainly through the upper airways of the host by inhalation of spores or propagules of the micro‐organism that settle initially in the lungs. Here, we describe a clinical case report of PCM acquired by a researcher following a scientific laboratory accident; to the best of our knowledge, this is the first report of infection with the yeast form of .

Case presentation:

A 40‐year‐old, white, healthy, male researcher, while undertaking experimental activities in a laboratory environment with fungus infection in guinea pigs, pierced the thumb of the left hand, with a 1 ml syringe containing 50 μl of a suspension of at a concentration of 1×10 c.f.u. ml. Seven days after the accident, the region had local swelling, redness and pain on stimulation. He was started on medical treatment and opted for surgical removal. A biopsy revealed an inflammatory infiltrate, numerous epithelioid granulomas and a discrete quantity of yeast organisms on the dermis, some with multiple budding yeast cells presenting characteristics of viability, with conclusive diagnosis of PCM. After 90 days of itraconazole treatment at 200 mg day, he reported healing with scar formation.

Conclusion:

The yeast form of is able to cause infection. According to our knowledge, this is the first time that this has been reported in the medical literature.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.000016
2015-02-01
2019-11-21
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/2/1/jmmcr000016.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.000016&mimeType=html&fmt=ahah

References

  1. Bagagli E., Theodoto R.C., Bosco S.M.G., McEwen J.G.. ( 2008;). Paracoccidioides brasiliensis: phylogenetic and ecological aspects. Mycopathologia165:197–207[CrossRef]
    [Google Scholar]
  2. Borges‐Walmsley M.I., Chen X., Walmsley A.R.. ( 2002;). The pathobiology of Paracoccidioides brasiliensis . Trends Microbiol10:80–87[CrossRef]
    [Google Scholar]
  3. Camargo Z.P., Franco M.F.. ( 2000;). Current knowledge on pathogenesis and immunodiagnosis of paracoccidioidomycosis. Rev Iberoam Micol17:41–48
    [Google Scholar]
  4. Franco M.F., Montenegro M.R.G., Mendes R.P., Marcos A.S., Dillon N.L., Mota N.G.S.. ( 1987;). Paracoccidioidomycosis: a recently proposed classification of its clinical forms. Rev Soc Bras Med Trop20:129–132[CrossRef]
    [Google Scholar]
  5. Giraldo R., Restrepo A., Gutierrez F., Londono Robledo. M., Hernandez F., Sierra H., F. Calle G.. ( 1976;). Pathogenesis of paracoccidioidomycosis: a model based on the study of 46 patients. Mycopathologia58:63–70[CrossRef]
    [Google Scholar]
  6. Lutz A.. ( 1908;). Uma mycose pseudococcidica localizada na bocca e observada no Brazil. Contribuição ao conhecimento das Hyphoblastomycoses americanas. O Brasil‐Medico. Revista Semanal de Medicina e Cirurgia22:121–124
    [Google Scholar]
  7. Mendes‐Giannini M.J., Monteiro da Silva J.L., Fátima da Silva J., Donofrio F.C., Miranda E.T., Andreotti P.F., Soares C.P.. ( 2008;). Interactions of Paracoccidioides brasiliensis with host cells: recent advances. Mycopathologia165:237–248[CrossRef]
    [Google Scholar]
  8. Negroni R.. ( 1993;). Paracoccidioidomycosis (South American blastomycosis, Lutz’s mycosis). Int J Dermatol32:847–859[CrossRef]
    [Google Scholar]
  9. Restrepo A.. ( 1985;). The ecology of Paracoccidioides brasiliensis: a puzzle still unsolved. Sabouraudia23:323–334[CrossRef]
    [Google Scholar]
  10. Roldán J.C., Tabares A.M., Gómez B.L., Aristizabal B.E., Cock A.M., Restrepo A.. ( 2000;). The oral route in the pathogenesis of paracoccidioidomycosis: an experimental study in BALB/c mice infected with P. . brasiliensis conidia. Mycopathologia151:57–62[CrossRef]
    [Google Scholar]
  11. San‐Blas G., Niño‐Vega G., Iturriaga T.. ( 2002;). Paracoccidioides brasiliensis and paracoccidioidomycosis: molecular approaches to morphogenesis, diagnosis, epidemiology, taxonomy and genetics. Med Mycology4:225–242[CrossRef]
    [Google Scholar]
  12. Valera E.T., Mori B.M., Engel E.E., Costa I.S., Brandão D.F., Nogueira‐Barbosa M.H., Queiroz R.G., Silveira V.d.S., Scrideli C.A., Tone L.G.. ( 2008;). Fungal infection by Paracoccidioides brasiliensis mimicking bone tumor. Pediatr Blood Cancer50:1284–1286[CrossRef]
    [Google Scholar]
  13. Wanke B., Londero A.T.. ( 1994;). Epidemiology and paracoccidioidomycosis infection. In Paracoccidioidomycosis109–120 Franco M, Lacaz C S, Restrepo‐Moreno A, Del Negro G. Boca Raton, FL: CRC Press;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.000016
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.000016
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error