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JMM Case Reports JMM Case Reports

Volume 2, Issue 1

Infection caused by the yeast form of Open Access

Abstract

Introduction:

Paracoccidioidomycosis (PCM) is caused by the dimorphic fungus . Infection occurs mainly through the upper airways of the host by inhalation of spores or propagules of the micro‐organism that settle initially in the lungs. Here, we describe a clinical case report of PCM acquired by a researcher following a scientific laboratory accident; to the best of our knowledge, this is the first report of infection with the yeast form of .

Case presentation:

A 40‐year‐old, white, healthy, male researcher, while undertaking experimental activities in a laboratory environment with fungus infection in guinea pigs, pierced the thumb of the left hand, with a 1 ml syringe containing 50 μl of a suspension of at a concentration of 1×10 c.f.u. ml. Seven days after the accident, the region had local swelling, redness and pain on stimulation. He was started on medical treatment and opted for surgical removal. A biopsy revealed an inflammatory infiltrate, numerous epithelioid granulomas and a discrete quantity of yeast organisms on the dermis, some with multiple budding yeast cells presenting characteristics of viability, with conclusive diagnosis of PCM. After 90 days of itraconazole treatment at 200 mg day, he reported healing with scar formation.

Conclusion:

The yeast form of is able to cause infection. According to our knowledge, this is the first time that this has been reported in the medical literature.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): accident , infection , Paracoccidioides brasiliensis and Paracoccidioidomycosis
© 2015 The Authors
  • This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/).
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2015-02-01
2025-03-19
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Infection caused by the yeast form of Paracoccidioides brasiliensis
JMM Case Rep 2, e000016 (2015); https://doi.org/10.1099/jmmcr.0.000016
/content/journal/jmmcr/10.1099/jmmcr.0.000016
/content/journal/jmmcr/10.1099/jmmcr.0.000016
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