1887

Abstract

Introduction:

Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) allows us to identify bacteria directly from positive blood cultures with detailed taxonomy naming of the bacterial strains. Knowing the name of the infective bacteria makes it possible to adjust the antibiotic therapy early on. However, it also gives rise to detection of a number of unusual pathogens, which raises new questions on the pathogenicity and medical importance of a number of rarely isolated bacteria such as .

Case presentation:

We describe a case of diabetic foot ulcers in a 45‐year‐old male, which led to below‐the‐knee amputation due to widespread infection and sepsis with and co‐infection with . The patient was treated initially with surgical debridement in combination with piperacillin/tazobactam and thereafter with amoxicillin for a total period of 1 month.

Conclusion:

Based on this case, as well as previous case reports in the literature, we conclude that is a rarely isolated low‐pathogenic bacterium in patients with severe co‐morbidities. Often co‐infection with other low‐pathogenic bacteria is observed. is susceptible to and readily treated with ‐lactam antibiotics.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.000006
2015-02-01
2019-11-19
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/2/1/jmmcr000006.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.000006&mimeType=html&fmt=ahah

References

  1. Adderson E.E., Croft A., Leonard R., Carroll K.. ( 1998;). Septic arthritis due to Arcanobacterium bernardiae in an immunocompromised patient. Clin Infect Dis27:211–212[CrossRef]
    [Google Scholar]
  2. Bemer P., Eveillard M., Touchais S., Redon H., Corvec S.. ( 2009;). A case of osteitis due to Staphylococcus aureus and Arcanobacterium bernardiae coinfection. Diagn Microbiol Infect Dis63:327–329[CrossRef]
    [Google Scholar]
  3. Clarke T.M., Citron D.M., Towfigh S.. ( 2010;). The conundrum of the Gram‐positive rod: are we missing important pathogens in complicated skin and soft‐tissue infections? A case report and review of the literature. Surg Infect (Larchmt)11:65–72[CrossRef]
    [Google Scholar]
  4. Funke G., Ramos C.P., Fernández‐Garayzábal J.F., Weiss N., Collins M.D.. ( 1995;). Description of human‐derived Centers for Disease Control coryneform group 2 bacteria as Actinomyces bernardiae sp. nov. Int J Syst Bacteriol45:57–60[CrossRef]
    [Google Scholar]
  5. Hijazin M., Alber J., Lämmler C., Weitzel T., Hassan A.A., Timke M., Kostrzewa M., Prenger‐Berninghoff E., Zschöck M.. ( 2012;). Identification of Trueperella (Arcanobacterium) bernardiae by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry analysis and by species‐specific PCR. J Med Microbiol61:457–459[CrossRef]
    [Google Scholar]
  6. Holler J.G., Pedersen L.K., Calum H., Nielsen J.B., Tvede M., Schønning K., Knudsen J.D.. ( 2011;). Using MALDI‐TOF mass spectrometry as a rapid and accurate diagnostic tool in infective endocarditis: a case report of a patient with mitral valve infective endocarditis caused by Abiotrophia defectiva . Scand J Infect Dis43:234–237[CrossRef]
    [Google Scholar]
  7. Ieven M., Verhoeven J., Gentens P., Goossens H.. ( 1996;). Severe infection due to Actinomyces bernardiae: case report. Clin Infect Dis22:157–158[CrossRef]
    [Google Scholar]
  8. Lepargneur J.P., Heller R., Soulié R., Riegel P.. ( 1998;). Urinary tract infection due to Arcanobacterium bernardiae in a patient with a urinary tract diversion. Eur J Clin Microbiol Infect Dis17:399–401
    [Google Scholar]
  9. Loïez C., Tavani F., Wallet F., Flahaut B., Senneville E., Girard J., Courcol R.J.. ( 2009;). An unusual case of prosthetic joint infection due to Arcanobacterium bernardiae. . J Med Microbiol58:842–843[CrossRef]
    [Google Scholar]
  10. Na’Was T.E., Hollis D.G., Moss C.W., Weaver R.E.. ( 1987;). Comparison of biochemical, morphologic, and chemical characteristics of Centers for Disease Control fermentative coryneform groups 1, 2, and A‐4. J Clin Microbiol25:1354–1358
    [Google Scholar]
  11. Otto M.P., Foucher B., Lions C., Dardare E., Gérôme P.. ( 2013;). Trueperella bernardiae soft tissue infection and bacteremia. Med Mal Infect43:487–489[CrossRef]
    [Google Scholar]
  12. Ramos C.P., Foster G., Collins M.D.. ( 1997;). Phylogenetic analysis of the genus Actinomyces based on 16S rRNA gene sequences: description of Arcanobacterium phocae sp. nov., Arcanobacterium bernardiae comb. nov., and Arcanobacterium pyogenes comb. nov. Int J Syst Bacteriol47:46–53[CrossRef]
    [Google Scholar]
  13. Weitzel T., Braun S., Porte L.. ( 2011;). Arcanobacterium bernardiae bacteremia in a patient with deep soft tissue infection. Surg Infect (Larchmt)12:83–84[CrossRef]
    [Google Scholar]
  14. Yassin A.F., Hupfer H., Siering C., Schumann P.. ( 2011;). Comparative chemotaxonomic and phylogenetic studies on the genus Arcanobacterium Collins et al., 1982 emend. Lehnen et al., 2006: proposal for Trueperella gen. nov. and emended description of the genus Arcanobacterium . Int J Syst Evol Microbiol61:1265–1274[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.000006
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.000006
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error