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Volume 58, Issue 3

Minimum inhibitory concentration of carbapenems and tigecycline against spp. Free

Abstract

Antimicrobial resistance in spp. is of grave concern, more so in quinolone-resistant and extended-spectrum -lactamase (ESBL)-producing isolates that cause complicated infections. The MIC of azithromycin, ciprofloxacin, cefixime, cefepime, ceftriaxone, gatifloxacin, imipenem, levofloxacin, meropenem and ofloxacin (E-test strip) and tigecycline and faropenem (agar dilution) against 210 spp. was determined. MIC (defined as the antimicrobial concentration thatinhibited growth of 90 % of the strains) of the carbapenems (imipenem and meropenem) for Typhi and Paratyphi A was 0.064 μg ml. MIC of faropenem was 0.25 μg ml for . Typhi, . Paratyphi A and Typhimurium. The MIC of azithromycin for all spp. ranged from 8 to 16 μg ml. Tigecycline showed an MIC of 2 μg ml for . Typhi, 1 μg ml for Paratyphi A and 4 μg ml for Typhimurium. We concluded that tigecycline and the carbapenems are likely to have roles in the final stage of treatment of quinolone-resistant and ESBL-producing multidrug-resistant salmonellae.

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  • Accepted:
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Keyword(s): CLSI, Clinical and Laboratory Standards Institute , ESBL, extended-spectrum β-lactamase , EUCAST, European committee on antimicrobial susceptibility testing , FDA, Food and Drug Administration , MDR, multidrug-resistant , MIC50 and MIC90, antimicrobial concentration that inhibited growth of 50 and 90 %, respectively, of the strains and NAR, nalidixic acid-resistant
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2009-03-01
2024-04-25
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Minimum inhibitory concentration of carbapenems and tigecycline against Salmonella spp.
J. Med. Microbiol. 58, 337 (2009); https://doi.org/10.1099/jmm.0.47853-0
/content/journal/jmm/10.1099/jmm.0.47853-0
/content/journal/jmm/10.1099/jmm.0.47853-0
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