1887

Abstract

is a pathogenic fungus that causes a superficial cutaneous infection called dermatophytosis, mainly in cats and humans. The mechanisms involved in adherence of to epidermis have never been investigated. Here, a model was developed to study the adherence of to feline corneocytes through the use of a reconstructed interfollicular feline epidermis (RFE). In this model, adherence of arthroconidia to RFE was found to be time-dependent, starting at 2 h post-inoculation and still increasing at 6 h. Chymostatin, a serine protease inhibitor, inhibited adherence to RFE by 53 %. Moreover, two mAbs against the keratinolytic protease subtilisin 3 (Sub3) inhibited adherence to RFE by 23 %, suggesting that subtilisins, and Sub3 in particular, are involved in the adherence process.

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2008-09-01
2020-04-06
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