1887

Abstract

The CmeABC efflux pump plays an important role in the antimicrobial resistance of and . The aim of this investigation was to study the effect of putative efflux pump inhibitors, phenyl-arginine--naphthylamide (PAN) and 1-(1-naphthylmethyl)-piperazine (NMP), as well as the effect of putative efflux pump inducers, sodium salicylate and sodium deoxycholate, on the MIC levels of erythromycin, ciprofloxacin, kanamycin, tetracycline and rifampicin for and . Our results indicated that susceptibility to erythromycin and rifampicin increased, respectively, 8- to 32- and 8- to 64-fold in the presence of PAN and to a lesser extent in the presence of NMP. Salicylate produced a 2- to 4-fold increase in ciprofloxacin MIC values, whereas little effect was observed in the presence of deoxycholate.

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2008-07-01
2020-08-05
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