1887

Abstract

Intracranial abscesses remain a significant health-care problem in developing countries. In view of this, we undertook a comprehensive study to determine the demographics and bacteriological spectrum of brain abscesses in our hospital. Bacteriological profiles and antibiograms were studied by conventional microbiological methods. Seventy-five patients were admitted with brain abscesses over a 5 year period (2001–2005). There was 9.5 % mortality in patients included in this study. The most important factors influencing mortality from intracranial abscess were the age and neurological condition of the patient at the time of admission. Brain abscess could develop at any age but there was a preponderance of males over females. Chronic suppurative otitis media was the most common predisposing factor for temporal lobe infections. Forty-one (54.70 %) abscesses were found to be due to pyogenic organisms, 4 % due to and 1.3 % were due to . The majority of microbial isolates were sensitive to the therapeutic regime adopted in our neurosurgery unit (cefotaxime, gentamicin and metronidazole). Chloramphenicol is another antibiotic with activity against the isolates.

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2008-10-01
2019-11-17
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References

  1. Ayyagari, A., Pancholi, V. K., Kak, V. K., Kumar, N., Khosla, V. K., Agarwal, K. C. & Gulati, D. R. ( 1983; ). Bacteriological spectrum of brain abscess with special reference to anaerobic bacteria. Indian J Med Res 77, 182–186.
    [Google Scholar]
  2. Baron, E. J., Peterson, L. R. & Finegold, S. M. ( 1994; ). Bailey and Scott’s Diagnostic Microbiology, 9th edn. St Louis, MO; CV Mosby Company.
  3. Bauer, A. W., Kirby, W. M. M., Herris, J. C. & Jurek, M. ( 1966; ). Antibiotic susceptibility testing by a standardized single method. Am J Clin Pathol 45, 493–496.
    [Google Scholar]
  4. Beller, A. J., Sahar, A. & Praiss, I. ( 1973; ). Brain abscess – review of 89 cases over a period of 30 years. J Neurol Neurosurg Psychiatry 36, 757–768.[CrossRef]
    [Google Scholar]
  5. Bhand, A. A. ( 2004; ). Brain abscess – diagnosis & management. J Coll Physicians Surg Pak 14, 407–410.
    [Google Scholar]
  6. Bharadwaj, R. & Joshi, B. N. ( 1988; ). Brain abscesses – a study of the causative organisms with special reference to anaerobes. Indian J Pathol Microbiol 31, 44–48.
    [Google Scholar]
  7. Calfee, D. P. & Wispelwey, B. ( 1999; ). Brain abscess, subdural empyema and intracranial epidural abscess. Curr Infect Dis Rep 1, 166–171.[CrossRef]
    [Google Scholar]
  8. Carey, M. E., Shelley, N., Chou, S. N. & French, L. A. ( 1972; ). Experience with brain abscesses. J Neurosurg 36, 1–9.[CrossRef]
    [Google Scholar]
  9. Chandramuki, A., Hegde, A. S. & Reddy, N. ( 1980; ). Anaerobic brain abscess – role of metronidazole in chemotherapy. Neurol India 28, 213–218.
    [Google Scholar]
  10. De, A., Das, P., Sharma, A. & Mathur, M. ( 2000; ). Bacteriology of intracranial abscesses with special reference to anaerobes. Indian J Med Microbiol 18, 184–188.
    [Google Scholar]
  11. De Louvois, J., Gortval, P. & Hurley, R. ( 1977; ). Bacteriology of abscesses of the central nervous system: a multicentre prospective study. Br Med J 2, 981–984.[CrossRef]
    [Google Scholar]
  12. Erdogan, E., Izci, Y., Dizer, U. & Baysefer, A. ( 2002; ). Multiple brain abscesses in a baby: case report and review of the literature. Ann Neurosurg 2, 1–6.
    [Google Scholar]
  13. Fischer, E. G., McLennan, J. E. & Suzuki, Y. ( 1981; ). Cerebral abscess in children. Am J Dis Child 135, 746–760.
    [Google Scholar]
  14. Gregory, D. H., Messner, R. & Zinnerman, H. H. ( 1967; ). Metastatic brain abscesses. A retrospective appraisal of 29 patients. Arch Intern Med 119, 25–31.[CrossRef]
    [Google Scholar]
  15. Han, S., Lim, D. J., Chung, Y. G., Cho, T. H., Lim, S. J., Kim, W. J., Park, J. Y. & Suh, J. K. ( 2002; ). The multiple brain abscesses associated with congenital pulmonary arterovenous malformations: a case report. J Korean Med Sci 17, 407–411.[CrossRef]
    [Google Scholar]
  16. Kagawa, M., Takeshita, M., Yato, S. & Kitamura, K. ( 1983; ). Brain abscess in congenital cyanotic heart disease. J Neurosurg 58, 913–917.[CrossRef]
    [Google Scholar]
  17. Kao, P.T., Tseng, H.K., Liu, C.P., Su, S. C. & Lee, C.M. ( 2003; ). Brain abscess: clinical analysis of 53 cases. J Microbiol Immunol Infect 36, 129–136.
    [Google Scholar]
  18. Karandanis, D. & Shulman, J. A. ( 1975; ). Factors associated with mortality in brain abscess. Arch Intern Med 135, 1145–1150.[CrossRef]
    [Google Scholar]
  19. Lakshmi, V., Rao, R. R. & Dinkar, I. ( 1993; ). Bacteriology of brain abscess – observation on 50 cases. J Med Microbiol 38, 187–190.[CrossRef]
    [Google Scholar]
  20. Larone, D. H. ( 1979; ). Medically Important Fungi: a Guide to Identification, 2nd edn. New York: Harper and Row.
  21. Mampalam, T. J. & Rosenblum, M. L. ( 1988; ). Trends in the management of bacterial brain abscess: a review of 102 cases over 17 years. Neurosurgery 23, 451–457.[CrossRef]
    [Google Scholar]
  22. Mathisen, G. E. & Johnson, J. P. ( 1997; ). Brain abscess. Clin Infect Dis 25, 763–781.[CrossRef]
    [Google Scholar]
  23. McClelland, C. J., Craig, B. F. & Crockard, H. A. ( 1978; ). Brain abscess in Northern Ireland: a 30-year community review. J Neurol Neurosurg Psychiatry 41, 1043–1047.[CrossRef]
    [Google Scholar]
  24. Morgan, H., Wood, M. & Murphy, F. ( 1973; ). Experience with 88 consecutive cases of brain abscess. J Neurosurg 38, 698–704.[CrossRef]
    [Google Scholar]
  25. Nathoo, N., Nadvi, S. S., van Dellen, J. R. & Gouws, E. ( 1999; ). Intracranial subdural empyemas in the era of computed tomography: a review of 699 cases. Neurosurgery 44, 529–536.[CrossRef]
    [Google Scholar]
  26. Ni, Y. H., Yeh, K. M., Peng, M. Y., Chou, Y. Y. & Chang, F. Y. ( 2004; ). Community-acquired brain abscess in Taiwan: etiology and probable source of infection. J Microbiol Immunol Infect 37, 231–235.
    [Google Scholar]
  27. Osma, U., Cureoglu, S. & Hosoglu, S. ( 2000; ). The complications of chronic otitis media: report of 93 cases. J Laryngol Otol 114, 97–100.
    [Google Scholar]
  28. Samson, D. S. & Clark, K. ( 1973; ). A current review of brain abscess. Am J Med 54, 201–210.[CrossRef]
    [Google Scholar]
  29. Seneviratne, R. S., Navasivaym, P., Perera, S. & Wickremasinghe, R. S. ( 2003; ). Microbiology of cerebral abscess at the neurosurgical unit of the National Hospital of Sri Lanka. Ceylon Med J 48, 14–15.
    [Google Scholar]
  30. Sinha, A. K., Mohanty, S., Sharma, V., Choudhury, A., Huda, M. F., Singh, V. P. & Tiwari, Y. A. ( 2003; ). A study of 268 consecutive cases of intracranial suppuration. Neurosciences Today 7,, 161–165.
    [Google Scholar]
  31. Sutton, D. A., Fothergill, A. W. & Michael, G. R. ( 1998; ). Guide to Clinically Important Fungi, 1st edn. Baltimore, MD: Williams & Wilkins.
  32. Willis, A. T. & Phillips, K. D. ( 1988; ). Gas liquid chromatography. In Anaerobic Infections Clinical and Laboratory Practice, pp. 128–139. London: Public Health Laboratory Service.
  33. Yang, S. Y. & Zhao, C. S. ( 1993; ). Review of 144 patients with brain abscess. Surg Neurol 39, 290–296.[CrossRef]
    [Google Scholar]
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