RT Journal Article SR Electronic(1) A1 John, Melanie-Anne A. A1 Rhemtula, Yasin A. A1 Menezes, Colin N. A1 Grobusch, Martin P.YR 2008 T1 Lamivudine-induced red cell aplasia JF Journal of Medical Microbiology, VO 57 IS 8 SP 1032 OP 1035 DO https://doi.org/10.1099/jmm.0.47782-0 PB Microbiology Society, SN 1473-5644, AB Anaemia is frequent in patients with human immunodeficiency virus infection, and antiretroviral drugs have been implicated. Whilst therapy-induced anaemia is more readily attributed to zidovudine, lamivudine-associated, potentially life-threatening, pure red cell aplasia (PRCA) has been less recognized in the past and is only infrequently documented in the literature. We report on a patient suffering from what turned out to be lamivudine-induced PRCA who required 15 units of blood within 3 weeks before recovering swiftly following lamivudine (3TC) treatment withdrawal. As reviewed here, the nature of this condition is not well described in general, the onset appears to be variable and occurs at any CD4+ count, but rapid improvement after cessation of drug administration appears to be a consistent feature., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47782-0